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International Journal of Bioprinting Semi-solid extrusion for pediatric medicine

Continued

Ref. 110 85 104 86 88 108 112 113 118 122 87 90 124 126 125 91 94 111 82 92

Long drying times can increase the risk of Freeze-drying creates a porous network accessible to water; hydration of the dosage form produces a thick gel, enabling longer active pharmaceutical ingredient (API) The drying step follows an ionic crosslinking step Drying is necessary for the evaporation of acetone Three drying conditions were tested: 70°C for 12 h, 40°C for 16h, and 37°C for 24 h; 37°C for 24 h demonstrated the easiest removal from

Commentaries recrystallization release prevent humidity uptake

Until obtaining a constant weight

Time Overnight 20 h 24 h 48 h 6 h Overnight Overnight 24 h 48 h 12 h 24 h No data 4 h 2 h 24 h 2.5 h 12 h

Temperature -80°C -80°C Room temperature Room temperature Room temperature Room temperature Room temperature Room temperature Room temperature 19.2 ± 0.9°C Ambient temperature 37°C 55°C (i) Oven-dried at 50°C for 4 h; then stored in the desiccator at 20°C for 24 h or refrigerated at 4°C for 72 h 50°C 80°C 50°C 40°C 40°C

Table 2. Drying conditions Drying method (i) Air-dried at 22.2°C for 48 h (ii) Freeze-drying at -80°C for 15 min; 15 h vacuum Freeze-drying Air-dried Oven-dried (ii) Oven-dried at 50°C for 24 h Oven-dried Oven-dried Vacuum oven drying Ventilated oven-dried (i) Air-dried at room temperature (ii) Microwave 200 W for 15 min (iii) Microwave 300 W for 10 min (iv) Microwave 400 W for 5 min (v) Oven-dried at 40°C for 7 h (vi) Vacuum drying at room tempera

Volume 10 Issue 6 (2024) 53 doi: 10.36922/ijb.4063