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International Journal of Bioprinting Semi-solid extrusion for pediatric medicine

Ref. 119 120 121 122 123 124 125 126

Feasibility assessment of manufacturing suppositories using SSE, with post-printing API loading via adsorption Poor water-soluble drugs; good self-emulsification; printing temperature (29°C) close to ambient temperature; an evaporative air cooler placed in front of the printer to ensure printing consistency Successful printing of well-defined suppositories containing biological, thermosensitive, and Disc- and mesh-shaped intravaginal devices dev

Commentaries hydrosensitive API mucoadhesive properties intravaginal use

Excipients Laponite; alginate Lauroyl macrogol-32 glycerides (Gelucire ® 44/14); coconut oil; N,N- dimethylacetamide Gelucire ® 44/14 or Gelucire ® 48/16; coconut oil; purified water Polycaprolactone; Gantrez TM -AN119 Sodium alginate; HPMC; aqueous solution: HEPES, CaCl 2 crosslinker Corn starch; β-glucan water suspension; glycerol; distilled water Mixture of vinyl-terminated polydimethylsiloxane (70%) and vinyl-methyl-modified silica

Methylene blue as the drug model Tofacitinib citrate; budesonide Metronidazole Pirfenidone Not available Metronidazole Secnidazole PVA/PVAc, poly(vinyl alcohol-co-vinyl acetate); PVA, polyvinyl alcohol; PVP, pyrrolidone; TPO, Diphenyl (2,4,6-trimethylbenzoyl) phosphine oxide.

API Infliximab

Formulation details and properties Suppositories made with laponite-alginate hydrogel Suppositories for local multidrug delivery Suppositories for local drug delivery Vaginal ovules Vaginal mucoadhesive ovules Skin patches for wound application 3D-printed silicone scaffolds for sustained release (intravaginal use) Anti-infective urinary catheter

Table 1. Continued Formulation type Suppositories or ovules Medical devices

Volume 10 Issue 6 (2024) 49 doi: 10.36922/ijb.4063