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RESEARCH ARTICLE

           Considerations Using Additive Manufacture of

           Emulsion Inks to Produce Respiratory Protective Filters

           Against Viral Respiratory Tract Infections Such as the

           COVID-19 Virus


           Colin Sherborne, Frederik Claeyssens*

           The Kroto Research Institute, North Campus, University of Sheffield, Broad Lane, Sheffield, S3 7HQ, UK

           Abstract: This review paper explores the potential of combining emulsion-based inks with additive manufacturing (AM) to
           produce filters for respiratory protective equipment (RPE) in the fight against viral and bacterial infections of the respiratory
           tract. The value of these filters has been highlighted by the current severe acute respiratory syndrome coronavirus-2 crisis
           where the importance of protective equipment for health care workers cannot be overstated. Three-dimensional (3D) printing
           of emulsions is an emerging technology built on a well-established field of emulsion templating to produce porous materials
           such as polymerized high internal phase emulsions (polyHIPEs). PolyHIPE-based porous polymers have tailorable porosity
           from the submicron to 100 s of µm. Advances in 3D printing technology enables the control of the bulk shape while a micron
           porosity is controlled independently by the emulsion-based ink. Herein, we present an overview of the current polyHIPE-based
           filter applications. Then, we discuss the current use of emulsion templating combined with stereolithography and extrusion-
           based AM technologies. The benefits and limitation of various AM techniques are discussed, as well as considerations for a
           scalable manufacture of a polyHIPE-based RPE.

           Keywords: Polymerized high internal phase emulsions; Emulsion templating; COVID-19; Additive manufacturing;
           Respirator protective equipment

           *Correspondence to: Frederik Claeyssens, The Kroto Research Institute, North Campus, University of Sheffield, Broad Lane, Sheffield, S3 7HQ,
           UK; F.Claeyssens@sheffield.ac.uk
            Received: October 20, 2020; Accepted: November 18, 2020; Published Online: January 13, 2021

           Citation:  Sherborne  C,  Claeyssens  F,  2021,  Considerations  Using Additive  Manufacture  of  Emulsion  Inks  to  Produce
           Respiratory  Protective  Filters Against  Viral  Respiratory  Tract  Infections  Such as the  COVID-19  Virus.  Int J Bioprint,
           7(1): 316.http://doi.org/10.18063/ijb.v7i1.316

           1. Introduction                                     the integrity of the fibers and remove their electrostatic
                                                               charge. Additive  manufacturing  (AM) has been  widely
           Personal  protective  equipment  (PPE)  and  respiratory   utilized  for  various  applications,  such  as  in  the  fields
           protective equipment (RPE) are vital for frontline health   of aerospace , automobiles , and tissue engineering ,
                                                                                                            [3]
                                                                                      [2]
                                                                         [1]
           workers that work with patients infected with contagious   and now, the  AM community has developed  three-
           respiratory  tract  infections,  such as the  coronavirus   dimensional  (3D)  printing  initiatives  to  support  health
           disease 2019 (COVID-19). During the early pandemic,   care and frontline workers .  This includes rapid
                                                                                        [4]
           there was an exceptionally high global demand for RPE   printable face shields for health care workers that can
           but supply chains were under severe  strain  and supply   reduce  direct  exposure from large airborne  respiratory
           continuality  remained  uncertain.  There is a constant   droplets . However, these initiatives are limited by the
                                                                     [5]
           demand for RPE masks as they are disposable items or   material choice and technology that produces masks for
           have a short lifetime as the filters need to be replaced or   respiratory protection. A key component of RPE is the
           decontaminated after prolonged use, which could damage   filtering mechanism. The filter traps and retains airborne

           © 2021 Sherborne and Claeyssens. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0
           International License (http://creativecommons.org/licenses/by-nc/4.0/), permitting all non-commercial use, distribution, and reproduction in any medium,
           provided the original work is properly cited.
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