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RESEARCH ARTICLE

Preparation of Graphene Oxide-loaded Nickel with

Excellent Antibacterial Property by Magnetic

Field-Assisted Scanning Jet Electrodeposition

Guibin Lou 1,2† , Ya Chen , Junwei Xu , Yingjuan Qian , Haixia Cheng , Zhen Wei , Youwen Yang *,
1
1†
4
5
1
3
Lida Shen *, Cijun Shuai 6
1,2
1 College of Mechanical and Electrical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016,
China
2 Key Laboratory of Digital Medical Equipment Technology of Jiangsu Province, Nanjing 210016, China
3 MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing
Agricultural University, Nanjing, 210095 China
4 Jiangsu Pharmaceutical Association, Nanjing 210016, China
5 Jiangxi University of Science and Technology, Ganzhou 341000, China
6 State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, China
† These authors contributed equally to this work

Abstract: Graphene oxide (GO) is recognized as a promising antibacterial material that is expected to be used to prepare a
new generation of high-efficiency antibacterial coatings. The propensity of GO to agglomeration makes it difficult to apply it
effectively. A new method of preparing GO-loaded nickel (GNC) with excellent antibacterial property is proposed in this paper.
In this work, GNC was prepared on a titanium sheet by magnetic field-assisted scanning jet electrodeposition. The massive
introduction of GO on the coating was proven by energy disperse spectroscopy and Raman spectroscopy. The antibacterial
performance of GNC was proven by agar plate assessment and cell living/dead staining. The detection of intracellular reactive
oxygen species (ROS) and the concentration of nickel ions, indicate that the antibacterial property of GNC are not entirely
derived from the nickel ions released by the coating and the intracellular ROS induced by nickel ions, but rather are due to the
synergistic effect of nickel ions and GO.
Keywords: Graphene oxide; Antibacterial coating; Jet electrodeposition; Nickel

*Correspondence to: Lida Shen, College of Mechanical and Electrical Engineering, Nanjing University of Aeronautics and Astronautics, 29 Yudao
Street, Nanjing 210016, China; ldshen@nuaa.edu.cn; Youwen Yang, Jiangxi University of Science and Technology, Ganzhou 341000, China;
yangyouwen@csu.edu.cn

Received: August 13, 2021; Accepted: September 14, 2021; Published Online: October 26, 2021
Citation: Lou G, Chen Y, Xu J, et al., 2022, Preparation of GO-loaded Nickel with Excellent Antibacterial Property by Magnetic Field-
Assisted Scanning Jet Electrodeposition. Int J Bioprint, 8(1):432. http:// doi.org/10.18063/ijb.v8i1.432

1. Introduction performance of surfaces, for example, in ships, petroleum
Microbial safety has attracted intense research interest pipeline metal structures, and medical implants [2-4] .
worldwide. Bacteria are widely distributed in nature, Antibacterial coatings have been mainly achieved using
[5]
and many can attach to the surface to form biofilms, three major strategies of contact-killing, antibacterial
posing a constant threat to human health and economy . agent release and anti-adhesion/bacteria-repellence [6-10] .
[1]
The prevention of bacterial colonization and infection At present, there is an increasing demand for improved
in human daily life and the working environment is performance of antibacterial surfaces in terms of
extremely important to human health. In addition, biofilm environmental friendliness, reliability, and efficiency.
will also reduce or even fully destroy the functional Thus, the development of a new generation of safe,
© 2021 Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution License, permitting distribution and
reproduction in any medium, provided the original work is properly cited.
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