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Liu, et al.
                                                               Table  2. Dimensions of samples obtained from L-PBF with
                                                               different correction factors
                                                               Correction     Length      Width        Height
                                                               Factor          (mm)
                                                               0.996         4.02±0.02   5.01±0.02   8.05±0.00
                                                               0.998         4.07±0.02   5.05±0.03   8.07±0.02
                                                               1.000         4.04±0.04   5.07±0.04   8.10±0.03
                                                               1.002         4.05±0.03   5.09±0.02   8.08±0.02
           Figure 2. Stripe scanning strategy used in L-PBF shows the fill   1.004  4.02±0.02  5.08±0.05  8.08±0.04
           contour and boarder offset, as well as the hatch spacing which is the
           distance between the two adjacent laser scan tracks.  Table  3.  Percentage  accuracy  of  samples  in  the  three  different
                                                               groups
           A               B            C                      Group           Accuracy      Min       Max
                                                               Comparison        (%)         (%)        (%)
                                                               Overall group   68.70%±5.63 −0.53±0.24 0.32±0.07
                                                               (Printed versus
                                                               actual tooth)
                                                               Printed group   90.59%±4.75 −0.12±0.10 0.27±0.06
                                                               (Segmented
                                                               versus printed
           Figure 3. Sample design used for preliminary studies to obtain the   tooth)
           correction factor. (A) Isometric view. (B) Top view. (C) Side view.  Segmentation   66.91%±10.51 −0.53±0.25 0.50±0.17
                                                               group
                                                               (Segmented
                                                               versus actual
                                                               tooth)


                                                               the additional imaging, segmentation, optimization  of
                                                               these steps and the “3D printing”  stage that involves
                                                               STL file preparation, the fabrication process, and post-
                                                               processing which may include polishing, safety testing,
                                                               and evaluation and finally, implant approval.
           Figure  4.  Extracted  monkey  incisor  and  the  3D-printed  dental   Our results showed 66.9% accuracy  in the
           implant, with their respective dimensions.          segmentation  process,  which  directly  influenced  the
                                                               accuracy of the fabricated implant. To test the fitting of
           real tooth can be attributed to the use of support structures   the 3D-printed dental implant within the monkey’s tooth
           at the incisal edge of the RAI during the L-PBF process.   socket, we performed a preliminary study and observed
           These support structures were removed subsequently   a slight protrusion of the 3D printed dental implant from
           before the comparison, which may result in inaccuracy at   the socket. This observation corroborated our accuracy
           the particular area .                               study, suggesting that  this  level  of accuracy  is likely
                          [13]
           (a)  Overall Group - Printed versus Actual Tooth    insufficient and will require further optimization to the
           (b)  Printed Group - Segmented versus Printed Tooth  segmentation and fabrication methodology to achieve a
           (c)  Segmentation  Group  -  Segmented  versus  Actual   complete insertion of the 3D printed dental implant into
              Tooth                                            the tooth socket.
                                                                   Having an intimate  and stable  fit  of  the  implant
           4. Discussion                                       within  the  bone defect  region  is one of critical  factors
                                                               contributing  to primary stability  of the dental implant.
           The  general  workflow  in  using  patient-specific  dental   Other factors such as bone quantity and quality, implant
           implants  is shown in  Figure  6.  Using  the  workflow,   design, surgical technique,  and insertion torque also
           we  identified  the  major  steps  in  obtaining  customized   influence  the  long-term  clinical  success  of  the  dental
           dental implants and studied the potential sources of error   implant  treatment [21,22] .  Without good biomechanical
           in the geometrical accuracy. The stages can be broadly   stability  upon implant  insertion, osseointegration  will
           categorized into the “implant design” stage which includes   not occur . The term, osseointegration, refers to a direct
                                                                      [12]
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