Page 59 - IJB-9-2

International Journal of Bioprinting Bioprinting in wound dressing and healing

neovascularization, and granulation tissue generation. The the actual demand and realize personalization in the
final stage is remodeling. Some of the mature sarcomeres medical field.
further differentiate into myofibroblasts. The type Ι collagen (ii) Multiple printhead arrays can be used for simultaneous
fraction in the extracellular matrix increases and becomes printing. This allows simultaneous use of different
the major fibronectin. Myofibroblast-forming cells interact types of cells, growth factors and biomaterials, and
with collagen bundles and growth factors to contract the precise control of the constituent materials and cells
wound and repair the skin. during the printing process according to the tissue-

Damage to the superficial epidermis of the skin can specific composition ratio, which is more conducive
be regenerated by self-renewal of the epidermis, leading to the construction of 3D scaffolds.
to wound repair and healing. However, self-repair is (iii) It can precisely locate the extrusion position of bioink
not possible for large areas of deep skin trauma and and control the amount of ink extrusion, enabling
manual intervention is often required for treatment . For positioning, and quantitative spot printing control.
[6]
significant skin defects and difficult-to-heal skin wounds, This helps build the internal microstructure of tissues
natural or artificial skin substitutes must be grafted on their and control the content of growth factors required
surfaces. However, the availability of autologous skin for for the internal growth of tissues, thus enabling local
transplantation is limited, and allogeneic or xenogeneic skin growth and development.
grafts have some immune rejection problems . Therefore,
[7]
there are significant limitations when using traditional The ability to create biological organs/tissues in a
methods to treat large skin lesions, and there is an urgent very short period ensures cell viability and promotes the
need to create artificial skin that can be used for skin grafts. development of regenerative medicine.
Biological three-dimensional (3D) printing technology Bioprinting occupies a significant position in
is the computer-controlled loading and delivery of pre- biomanufacturing, and its concept and technology
designed 3D models with precise positioning of bioink realization is closely related to the rapid development of
to manufacture human tissue . Bioprinting is more life science informatics, material science, manufacturing
[8]
compatible with human ergonomic design than tissue science, engineering science, and other disciplines. To
engineering culture methods. The concept of bioprinting date, many reviews on bioprinting technologies have
technology was first introduced by Mironov et al. [9,10] in been published [18-23] , some of which focus specifically
2003. During their exploratory studies, they found that the on applications in wound dressing and healing [24-27] .
embryonic heart tubes of chicks were cut into separate rings Bibliometric analysis is a literature and information
of cardiomyocytes. The rings of cells were arranged densely mining method based on mathematical statistics. It can
on a ring-shaped scaffold and could be fused over time in reflect research trends and hotspots through clustering
culture to form a tubular structure similar to a blood vessel. relationships of keywords in the literature and has
They thus proposed for the first time “cell printing,” which become an important tool for global analysis in various
accurately stacks cells and materials into 3D bodies with a scientific fields [28-36] . Among them, bibliometrics has been
specific morphological structure, just like printing. The cells applied to the analysis of 3D printing-related topics. For
grow by proliferation, fusing themselves into tissues or organs example, Rodríguez-Salvador et al. [37] analyzed scientific
and eventually generating tissues. Wilson and Boland publications and patents in the field of 3D printing for
[11]
performed the printing of bovine aortic vascular endothelial the purpose of understanding the state of development
cells and bovine serum proteins labeled by fluorescein in the of this field and analyzed the institutions and companies
same year and found that the printed vascular endothelial that have important role in this field. In another work [38] ,
cells and serum proteins were still active. they used the competitive technology intelligence
cycle to perform another scientometric analysis of
There are several bioprinting technologies, divided
into three main types: material extrusion (mechanical bioprinting technologies. In this work, they focused on
authors and affiliations. Naveau et al.
also performed
[39]
and pneumatic) bioprinting [12,13] , material jetting (inkjet, a similar analysis in this area, although they mainly used
microvalve, laser-assisted, acoustic) bioprinting [14,15] , VOSviewer as the analysis software. In recent years,
and vat polymerization (stereolithography, digital light bibliometrics has been further applied to the analysis
processing, two-photon polymerization) [16,17] . Compared of various directions in the field of 3D printing. For
with traditional tissue engineering research methods, the example, Rodriguez-Salvador et al. recently analyzed the
main advantages of bioprinting are as follows:
research dynamics of tissue spheroids [40] and bioinks
[41]
(i) The accurate 3D image processing platform can using bibliometrics. We focused on another application
manufacture suitable organs or tissues according to direction of 3D printing.

Volume 9 Issue 2 (2023) 51 http://doi.org/10.18063/ijb.v9i2.653