Page 191 - IJB-9-4

International Journal of Bioprinting 3D-printed middle ear prostheses

Acknowledgments project can be published within the framework of permits
and legislation.
We want to thank M.Sc. (Tech) Pekka Paavola for photo
stacking technique photographing. We also want to thank Further disclosure
Ph.D. Jukka Kuva (Geological Survey of Finland, Espoo,
Finland) for collaboration with regard to micro-CT Part of the findings has been presented in the 6th Congress
imaging. X-ray tomography was supported by the Academy of European ORL-HNS, Milan, Italy, October 29–
of Finland via RAMI infrastructure project (#293109). November 2, 2022.

Funding References

This study has been funded by the Tauno Palva Foundation, 1. Luers JC, Hüttenbrink KB, 2016, Surgical anatomy and
the Helsinki University Hospital Research Fund and the pathology of the middle ear. J Anat, 228(2):338–353.
Academy of Finland Grant 325509. https://doi.org/10.1111/joa.12389
Conflict of interest 2. Rondini-Gilli E, Grayeli AB, Borges Crosara PF, et al.,
2003, Ossiculoplasty with total hydroxylapatite prostheses
The authors declare that the research was conducted in the anatomical and functional outcomes. Otol Neurotol,
absence of any commercial or financial relationships that 24(4):543–547.
could be construed as a potential conflict of interest. https://doi.org/10.1097/00129492-200307000-00003

Author contributions 3. Colletti V, Carner M, Colletti L, 2009, TORP vs round
window implant for hearing restoration of patients
Conceptualization: All authors with extensive ossicular chain defect. Acta Otolaryngol,
Formal analysis: Anssi-Kalle Heikkinen, Sini Lähde, 129(4):449–452.
Valtteri Rissanen, Antti Mäkitie, Ville Sivonen, Saku https://doi.org/10.1080/00016480802642070
T. Sinkkonen
Investigation: Anssi-Kalle Heikkinen, Sini Lähde, Valtteri 4. Alaani A, Raut VV, 2010, Kurz titanium prosthesis
ossiculoplasty—Follow-up statistical analysis of factors
Rissanen, Mika Salmi, Ville Sivonen, Saku T. affecting one year hearing results. Auris Nasus Larynx,
Sinkkonen 37(2):150–154.
Supervision: Ville Sivonen, Saku T. Sinkkonen
Writing – original draft: Anssi-Kalle Heikkinen, Sini Lähde, https://doi.org/10.1016/j.anl.2009.05.004
Ville Sivonen, Saku T. Sinkkonen 5. Yung M, Smith P, 2010, Titanium versus nontitanium
Writing – review & editing: All authors ossicular prostheses—A randomized controlled study of the
medium-term outcome. Otol Neurotol, 31(5):752–758.
Ethics approval and consent to participate https://doi.org/10.1097/MAO.0b013e3181de4937

The study fulfilled the Helsinki Declaration for ethical use 6. Babighian G, Albu S, 2011, Stabilising total ossicular
of human material. Institutional Review Board (IRB) at replacement prosthesis for ossiculoplasty with an absent
Helsinki University Hospital approved the study protocol malleus in canal wall down tympanomastoidectomy—A
and the use of anonymous cadaveric temporal bones in randomised controlled study. Clin Otolaryngol, 36(6):543–549.
the study (approval no. §49/29.10.2020, HUS/58/2020). https://doi.org/10.1111/j.1749-4486.2011.02406.x
These temporal bones were dissected at the Department 7. Hess-Erga J, Møller P, Vassbotn FS, 2013, Long-term hearing
of Forensic Medicine, Helsinki University with the result using Kurz titanium ossicular implants. Eur Arch
permission of National Supervisory Authority for Welfare Otorhinolaryngol, 270(6):1817–1821.
and Health (permission no. 6834/06.01.03.01/2013).
https://doi.org/10.1007/s00405-012-2218-x
Consent for publication 8. Chen Z, Sun X, Zhou H, et al., 2014, Comparison of
hearing results of malleovestibulopexy and total ossicular
Not applicable. replacement prosthesis for chronic otitis media patients
with a mobile stapes footplate. Ann Otol Rhinol Laryngol,
Availability of data 123(5):343–346.
All the 3D models of the study in STL format can be found https://doi.org/10.1177/0003489414526366
from an open-source database (https://doi.org/10.5281/ 9. Fayad JN, Ursick J, Brackmann DE, et al., 2014, Total
zenodo.7281752). If needed, the other data of this research ossiculoplasty: Short- and long-term results using a

Volume 9 Issue 4 (2023) 183 https://doi.org/10.18063/ijb.727