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International Journal of Bioprinting

REVIEW ARTICLE
Evolution of bioprinting and current applications

Laura Mendoza-Cerezo , Jesús M. Rodríguez-Rego *, Antonio Macías-García ,
1
1
2
Alfonso C. Marcos-Romero , Antonio Díaz-Parralejo 2
1
1 Departamento de Expresión Gráfica, Escuela de Ingenierías Industriales, Universidad de
Extremadura, Avenida de Elvas, s/n. 06006-Badajoz, Spain
2 Departamento de Ingeniería Mecánica, Energética y de los Materiales, Escuela de Ingenierías
Industriales, Universidad de Extremadura, Avenida de Elvas, s/n. 06006-Badajoz, Spain

Abstract
Bioprinting is a very useful tool that has a huge application potential in different fields
of science and biotechnology. In medicine, advances in bioprinting are focused on
the printing of cells and tissues for skin regeneration and the manufacture of viable
human organs, such as hearts, kidneys, and bones. This review provides a chronological
overview of some of the most relevant developments of bioprinting technique and
its current status. A search was carried out in SCOPUS, Web of Science, and PubMed
databases, and a total of 31,603 papers were found, of which 122 were finally chosen
for analysis. These articles cover the most important advances in this technique at the
medical level, its applications, and current possibilities. Finally, the paper ends with
conclusions about the use of bioprinting and our expectations of this technique. This
paper presents a review on the tremendous progress of bioprinting from 1998 to the
present day, with many promising results indicating that our society is getting closer
to achieving the total reconstruction of damaged tissues and organs and thus solving
many healthcare-related problems, including the shortage of organ and tissue donors.
*Corresponding author:
Jesús M. Rodríguez-Rego
(jesusrodriguezrego@unex.es) Keywords: Bioprinting; 3D printing; Tissue engineering; Organ culture; Tissue
Citation: Mendoza-Cerezo L, regeneration
Rodríguez-Rego JM, Macías-
García A, et al., 2023, Evolution of
bioprinting and current applications.
Int J Bioprint, 9(4): 742.
https://doi.org/10.18063/ijb.742 1. Introduction
Received: February 23, 2023 Three-dimensional (3D) bioprinting, which can be defined as a technique used to print
Accepted: March 15, 2023 living cells in a pre-designed pattern , is an innovative technology that is still in its
[1]
Published Online: May 2, 2023
infancy. Bioprinting has a huge application potential in many disciplines of science and
Copyright: © 2023 Author(s). biotechnology. Particularly, in the field medicine, bioprinting is utilized to print cells and
This is an Open Access article tissues for the purposes of skin regeneration and manufacture of viable human organs,
distributed under the terms of the
Creative Commons Attribution including hearts, kidneys, and bones.
License, permitting distribution,
and reproduction in any medium, Bioprinting has undergone an enormous evolution within the recent decade, and it
provided the original work is is expected to bring about revolution to the modern medicine. Specifically, bioprinting
properly cited. can be applied to develop new therapies in the form of newly generated organs for
Publisher’s Note: Whioce autologous transplants in patients.
Publishing remains neutral with
regard to jurisdictional claims in In this review, we aim to present a chronological overview of the most relevant
published maps and institutional developments of bioprinting technique and its current status after a thorough search of
affiliations.

Volume 9 Issue 4 (2023) 367 https://doi.org/10.18063/ijb.742