Page 23 - IJB-9-5

International Journal of Bioprinting

REVIEW ARTICLE
3D bioprinting strategy for engineering

vascularized tissue models

Suhun Chae , Dong-Heon Ha *, Hyungseok Lee *
2,3
1
1
1 EDmicBio Inc., Seoul 02458, Republic of Korea
2 Department of Mechanical and Biomedical Engineering, Kangwon National University, Chuncheon
24341, Republic of Korea
3 Department of Smart Health Science and Technology, Kangwon National University, Chuncheon
24341, Republic of Korea
(This article belongs to the Special Issue: 3D Printing of Advanced Biomedical Devices)

Abstract

Leveraging three-dimensional (3D) bioprinting in the fields of tissue engineering and
regenerative medicine has rapidly accelerated progress toward the development
of living tissue constructs and biomedical devices. Ongoing vigorous research has
pursued the development of 3D in vitro tissue models to replicate the key aspects
of human physiology by incorporating relevant cell populations and adequate
environmental cues. Given their advantages of being able to intimately mimic the
heterogeneity and complexity of their native counterparts, 3D in vitro models hold
promise as alternatives to conventional cell cultures or animal models for translational
application to model human physiology/pathology and drug screening. Research has
highlighted the importance of in vitro models, and a sophisticated biomanufacturing
strategy is vitally required. In particular, vascularization is critical for the prolonged
*Corresponding authors: survival and functional maturation of the engineered tissues, which has remained one
Dong-Heon Ha of the major challenges in the establishment of physiologically relevant 3D in vitro
(matt@edmicbio.com) models. To this end, 3D bioprinting can efficiently generate solid and reproducible
Hyungseok Lee vascularized tissue models with high architectural and compositional similarity to
(ahl@kangwon.ac.kr)
the native tissues, leading to improve the structural maturation and tissue-specific
Citation: Chae S, Ha D-H, Lee H, functionality. Multiple bioprinting strategies have been developed to vascularize in
2023, 3D bioprinting strategy for vitro tissues by spatially controlled patterning of vascular precursors or generating
engineering vascularized tissue
models. Int J Bioprint, 9(5): 748. readily perfusable vascular structures. This review presents an overview of the
https://doi.org/10.18063/ijb.748 advanced 3D bioprinting strategies for vascularized tissue model development. We
Received: February 16, 2023 present the key elements for rebuilding functional vasculature in 3D-bioprinted tissue
Accepted: March 28, 2023 models and discuss the recent achievements in the engineering of 3D vascularized
Published Online: May 9, 2023 in vitro models using 3D bioprinting. Finally, we delineate the current challenges and
Copyright: © 2023 Author(s). future outlooks of 3D bioprinting-based vascularized tissue models.
This is an Open Access article
distributed under the terms of the
Creative Commons Attribution Keywords: 3D bioprinting; Vascular tissue models; Organ-on-a-chip; Biofabrication;
License, permitting distribution, In vitro models
and reproduction in any medium,
provided the original work is
properly cited.
Publisher’s Note: Whioce 1. Introduction
Publishing remains neutral with
regard to jurisdictional claims in Three-dimensional (3D) in vitro models, such as organ-on-a-chip or micro-
published maps and institutional
affiliations. physiological systems, refer to biomimetic ex vivo miniaturized platforms mimicking

Volume 9 Issue 5 (2023) 15 https://doi.org/10.18063/ijb.748