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Innovative Medicines & Omics Rocuronium versus succinylcholine in general anesthesia

and 40 patients from Group 1 and forty patients from in any of the groups. One patient from Group 1 and three
Group 2 had strong jaw relaxation (score of 3). When the from Group 2 had a mild cough (score of 1). Six patients
two groups’ jaw relaxations are compared, it is discovered from Group 1 and 23 patients from Group 2 exhibited the
that the difference between the groups is statistically not diaphragm movement (scoring of 2). It is interesting to
significant (P = 0.507) and that the P-value is more than note that 24 patients in Group 2 and 43 patients in Group 1
0.05. The closed vocal cord movement (score of 0) was did not react to intubation (score of 3). The P-value for
not found in any of the groups. The closing vocal cord intubating response is observed to be <0.005. It follows
movement (score of 1) was found in 2 patients of Group 2. that there is a highly significant difference in the intubating
The moving vocal cord movement (score of 2) was found response between the two groups (P = 0.000).
in 5 patients of Group 1 and 9 patients of Group 2. A total Table 4 displays the HR and SpO at different intervals
2
of 45 patients from Group 1 and 39 patients from Group 2 (basal, pre-induction, and post-induction at 1, 3, and
had open vocal cord movement (scoring of 3). The vocal 5 min, respectively). The HR and SpO at different intervals
2
cord movement between the two groups is compared, and have been found to be statistically insignificant despite the
the P-value is shown to be greater than 0.05. Thus, the vocal fact that the P-value for both variables is more than 0.05.
cord movement in both groups is found to be comparable
(P = 0.168). The bucking coughing (score of 0) was not found The SBP, DBP, and MAP are displayed in Table 5 at
various intervals (base, pre-induction, and post-induction
at 1, 3, and 5 min, respectively). The P-values for SBP, DBP,
Table 2. Intubating conditions of Group 1 (succinylcholine)
and Group 2 (rocuronium) and MAP were >0.05. In comparison, the data have been
observed to be statistically insignificant. Table 6 presents
Intubating conditions (n [%]) Group 1 Group 2 P‑value the data collected for the mean onset of action. Groups 1
Excellent 47 (94%) 44 (88%) and 2 had mean onsets of action of 56.42 ± 1.14 and
Good 3 (6%) 5 (10%) 0.456 a 56.36 ± 1.08 s, respectively. The findings revealed that the
Fair 0 (0%) 1 (2%) values are statistically insignificant and that the P-value is
higher than 0.05.
Poor 0 (0%) 0 (0%)
Acceptable 50 (100%) 49 (98%) >0.05 4. Discussion
Unacceptable 0 (0%) 1 (2%) The study compared the hemodynamic characteristics,
Note: Chi-square test. ease of intubation, and onset time between succinylcholine
a
Table 3. Patients in Groups 1 (succinylcholine) and Table 4. Average HR and SpO in Groups 1 (succinylcholine)
2
2 (rocuronium) regarding jaw relaxation, vocal cord and 2 (rocuronium) at various intervals
movement, and intubating response
Clinical Group 1 Group 2 P‑value b
Clinical parameters Group 1 Group 2 P‑value parameters (mean±SD) (mean±SD)
Jaw relaxation (n [%]) HR
0 (Poor) 0 (0%) 0 (0%) 0.507 a Basal 83.46±14.11 83.08±12.49 0.887
1 (Minimal) 0 (0%) 1 (2%) Pre-induction 84.64±14.52 82.86±13.49 0.527
2 (Moderate) 7 (14%) 9 (18%) Post-induction 91.84±13.41 90.14±14.32 0.541
3 (Good) 43 (86%) 40 (80%) (1 min)
0 (Closed) 0 (0%) 0 (0%) 3 min 84.70±14.21 85.68±13.72 0.726
Vocal cord movement (n [%]) 5 min 85.16±11.07 84.46±13.20 0.775
1 (Closing) 0 (0%) 2 (4%) 0.168 a SpO 2
2 (Moving) 5 (10%) 9 (18%) Basal 99.76±0.43 99.76±0.43 0.378
3 (Open) 45 (90%) 39 (78%) Pre-induction 99.74±0.56 99.74±0.56 1.000
0 (Bucking coughing) 0 (0%) 0 (0%) Post-induction 99.80±0.40 99.80±0.40 1.000
(1 min)
Intubating response (n [%])
3 min 99.82±0.39 99.82±0.39 1.000
1 (Slight coughing) 1 (2%) 3 (6%) 0.000 a
5 min 99.76±0.43 99.76±0.43 1.000
2 (Diaphragm movement) 6 (12%) 23 (46%) <0.005
Note: * t-test.
b
3 (None) 43 (86%) 24 (48%) Abbreviations: HR: Heart rate; SD: Standard deviation; SpO : Oxygen
Notes: Chi-square test. saturation. 2
a
Volume 1 Issue 1 (2024) 110 doi: 10.36922/imo.3196