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Innovative Medicines & Omics Rocuronium versus succinylcholine in general anesthesia

Table 5. SBP, DBP, and MAP of individuals in Groups 1 and 52 ± 21, respectively. In the 80.0% and 86.7% of patients
(succinylcholine) and 2 (rocuronium) who received 1.0 mg/kg and 2 mg/kg succinylcholine,
respectively, the intubating circumstances were favorable.
Clinical Group 1 Group 2 P‑value b
parameters (mean±SD) (mean±SD) The probit analysis yielded succinylcholine dosages of
SBP 0.39 (0.29 – 0.51) and 1.6 (1.2 – 2) mg/kg, respectively, that
are required to generate excellent intubating conditions in
Basal 133.98±14.52 129.70±18.23 0.234 50% and 80% of patients at 60 s. The authors concluded
Pre-induction 130.68±17.51 128.68±13.93 0.528 that in rapid sequence anesthesia, there is no advantage to
Post-induction 138.32±15.37 137.82±20.64 0.891 giving succinylcholine doses higher than 1.5 mg/kg.
(1 min)
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3 min 126.64±14.10 126.08±16.85 0.857 Misra et al. studied 90 patients classified as
5 min 118.48±16.02 116.44±12.39 0.478 ASA I or II, divided into three groups: Group I was
given 1.5 mg/kg of succinylcholine, Group II was given
DBP 0.6 mg/kg of rocuronium, and Group III was given
Basal 91.68±14.52 91.52±13.02 0.954 0.1 mg/kg of vecuronium. With succinylcholine, 90% of
Pre-induction 89.34±13.17 88.28±10.44 0.657 patients achieved excellent intubating conditions, with an
Post-induction 98.22±13.14 99.62±14.67 0.616 additional l6.7% achieving good intubating conditions;
(1 min) one patient experienced a fair intubating condition using
3 min 83.02±10.40 78.78±13.47 0.081 1.5 mg/kg of succinylcholine. In Group II, 70% of patients
5 min 78.64±7.88 78.52±9.80 0.946 achieved good intubating conditions at 60 s, while none in
MAP Group III achieved excellent intubating conditions at 60 s.
Basal 105.78±13.71 104.25±13.60 0.576 At 90 s, all patients in the rocuronium group had acceptable
Pre-induction 103.12±13.37 101.75±10.83 0.574 intubating conditions. These results align with those of
Raizada et al. On the other hand, patients intubated
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Post-induction 111.59±12.10 112.35±15.53 0.784 with rocuronium (1.2 mg/kg body weight) demonstrated
(1 min)
3 min 97.56±10.02 94.55±13.28 0.203 clinically acceptable conditions in 98% of patients in
Group II. Excellent intubation conditions were noted in
5 min 91.92±8.83 91.20±9.70 0.715 88% of patients, while good intubating conditions were
Note: * t-test. noted in 10% of the patients in Group II. Fair intubating
b
Abbreviations: SBP: Systolic blood pressure; DBP: Diastolic blood conditions were noted in one patient (2%) from Group II.
pressure; MAP: Mean arterial pressure.
The research was in line with the results published by
Mazurek et al., indicating no significant difference in the
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Table 6. Mean onset of action for Groups 1 (succinylcholine)
and 2 (rocuronium) overall acceptable intubating conditions between these
groups (P ≥ 0.05).
Clinical parameter Group 1 Group 2 P‑value b 26
(mean±SD) (mean±SD) Raizada et al. conducted a study comparing different
Onset of action 56.42±1.14 56.36±1.08 0.788 dosages of rocuronium for endotracheal intubation. In this
trial, sixty ASA I and II patients were enrolled and randomly
Notes: t-test.
b
assigned to three groups: Group A received 0.6 mg/kg of
rocuronium, Group B received 0.9 mg/kg, and Group C
and rocuronium. Our findings align with those of Naguib received 1.2 mg/kg. As premedication, the patients received
et al., who reported similar results. In Group 1, patients injections of midazolam (0.05 mg/kg), glycopyrrolate
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intubated with succinylcholine (1.2 mg/kg body weight) (0.001 mg/kg), dansetron (0.1 mg/kg), and fentanyl
demonstrated clinically acceptable conditions in 100% of (1 mcg/kg), followed by induction with 2 mg/kg of propofol.
cases, excellent intubating conditions in 94% and good The majority of patients in Group A (50%), Group B
conditions in 6%. However, our findings contrast with (75%), and Group C (90%) achieved excellent intubating
those of Misra et al., who observed clinically unacceptable conditions. Researchers discovered that rocuronium at
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conditions in one case with succinylcholine, potentially 1.2 mg/kg (intravenous) had a speedier onset, longer
attributed to a larger dose. duration, and better intubating conditions compared to
Naguib et al. conducted a study involving 180 adult ASA 0.9 mg/kg and 0.6 mg/kg doses. A total of 26 children aged
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I patients undergoing elective surgery procedures. They 2 – 15 with ASA I–III were studied by Mazurek et al.
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discovered that the mean onset of succinylcholine at doses Every child who was recruited had emergency surgery
of 0.5, 1.0, 1.5, and 2.0 mg/kg was 68 ± 44, 53 ± 23, 56 ± 31, and needed rapid sequence intubation (RSI). Each patient

Volume 1 Issue 1 (2024) 111 doi: 10.36922/imo.3196