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Innovative Medicines & Omics Rocuronium versus succinylcholine in general anesthesia

prospective, randomized, single-blind, and controlled shifted to the recovery unit, where oxygen supplementation
investigation was approved by the institutional ethics was delivered through face mask.
committee. Written informed consent was obtained from
all participating patients. 3. Results
2.2. Participants The mean age in years for Groups 1 and 2 was 47.38 ± 11.42
and 44.84 ± 5.94, respectively. The ASA Grade I status in
The study included 100 patients categorized as the Groups 1 and 2 was 42 patients (84%) and 47 patients (94%),
American Society of Anesthesiologists (ASA) status I whereas the ASA Grade II status in both groups was 8 (16%)
and II, aged 18 – 60, and with Mallampati (MP) scores of and 3 (6%), respectively. The mean weight in kilograms
I or II undergoing elective surgery. Patients with a body for Groups 1 and 2 was 54.84 ± 10.33 and 51.80 ± 8.72,
mass index (BMI) >30, a history of difficult intubation, MP respectively. The Mallampati Grade I score in Groups 1
grades III and IV, and co-morbidities, such as hypertension, and 2 was 43 (86%) and 45 (90%), whereas the Mallampati
cervical spine disease, cardiac disease, and hepatic, and Grade II score in both groups was 7 (14%) and 5 (10%),
renal disease were not included in the analysis. The student respectively. In Group 1 and Group 2, the male-to-female
t-test and the Chi-square test were employed in this study ratios were 25 (50%)/25 (50%) and 24 (48%)/26 (52%),
to compare results. All patients underwent vital routine respectively. The ASA grades, age, weight, Mallampati
examinations, and their preanesthetic checkup charts score, and sex of the groups did not significantly differ
were reviewed the day before surgery. Before the surgery, from one another. The P-value found is >0.05, as shown
patients were instructed to fast for 12 h. in Table 1. In 94% of patients, succinylcholine generated
2.3. Interventions “excellent” intubating conditions; rocuronium, on the other
hand, produced “excellent,” “good,” and “fair” conditions in
Following their preanesthetic examination, patients 88%, 10%, and 2% of patients, respectively. Both groups
were randomly divided into two groups of 50 each. have had no instances of unsuccessful intubation. The
Group 1 received intravenous succinylcholine at a dose general intubating circumstances between the two groups
of 1.2 mg/kg, followed by 60 s of intubation. Group 2 was were evaluated and found to be statistically insignificant.
intubated after 60 s and given 1.2 mg/kg of rocuronium
intravenously. Premedication included a reliable dose In Table 2, clinically acceptable conditions have been
of anticholinergic drugs (anxiolytics and antiemetics). found in 50 (100%) patients in Group 1 and 49 (98%)
Preoxygenation with 100% oxygen for 3 – 5 min was patients in Group 2. The difference between the two groups
conducted, followed by induction with 1% propofol at has been observed to be statistically insignificant.
a dose of 2 mg/kg. Muscle paralysis for intubation was Table 3 displays the intubating response, vocal cord
attained with either intravenous succinylcholine 1.2 mg/kg movement, and jaw relaxation. The poor jaw relaxation
(Group 1) or intravenous rocuronium 1.2 mg/kg (Group 2). (score of 0) was not found in any of the groups. One patient
A laryngoscopy was performed at 60 s, and the onset time from Group 2 had the least amount of jaw relaxation (score
and ease of intubation were recorded. of 1), whereas seven patients from Group 1 and nine patients
Using the scale developed by Cooper et al., the from Group 2 had moderate jaw relaxation (score of 2)
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intubating circumstances of patients in both groups were
evaluated. The intubation time was recorded after securing Table 1. Demographic data of Group 1 (succinylcholine) and
the tracheal intubation, and the tube was secured and Group 2 (rocuronium)
connected to the breathing circuit. Using a multimodality Characteristics Group 1 Group 2 P‑value
monitor, the following parameters were recorded: heart Age in years 47.38±11.42 44.84±5.94 0.166 b
rate (HR), systolic and diastolic blood pressure (SBP (mean±SD)
and DBP), mean arterial pressure (MAP), and oxygen ASA (I/II) 42 (84%)/8 (16%) 47 (94%)/3 (6%) 0.110 a
saturation (SpO ) at 1-, 3-, and 5-min intervals. Oxygen Weight in kg 54.84±10.33 51.80±8.72 0.115 b
2
and nitrous oxide in a 1:3 ratio, 1% inhalational agents, (mean±SD)
and a consistent dosage of muscle relaxant were used to Mallampati 43 (86%)/7 (14%) 45 (90%)/5 (10%) 0.538 a
maintain anesthesia. Toward the end of the procedure, a score (I/II)
suitable dose of the anticholinesterase agent, along with Sex 25 (50%)/25 (50%) 24 (48%)/26 (52%) 0.841 a
an antisialagogues agent, was administered intravenously (male/female)
to reverse the impact of the neuromuscular agent. After Notes: Chi-square test; t-test.
a
b
ensuring sufficient inversion, extubation was performed, Abbreviations: ASA: American Society of Anesthesiologists;
and patients in the anti-Trendelenburg position were SD: Standard deviation.

Volume 1 Issue 1 (2024) 109 doi: 10.36922/imo.3196