Page 113 - IMO-1-1

Innovative Medicines & Omics

ORIGINAL RESEARCH ARTICLE
Comparison of rocuronium and

succinylcholine: Onset of action, ease of
intubation, and hemodynamic parameters

during general anesthesia

Hanan Shakeel 1,2 , Aditya Sharma 1 , and Vikrant Abbot *
3
1 Department of Anaesthesiology, Maharishi Markandeshwar Deemed to be University, Mullana,
Ambala, Haryana, India
2 Department of Anesthesia and Operation Theatre Technology, Faculty of Pharmaceutical and Allied
Sciences, Saraswati Group of Colleges, Gharuan, Mohali, Punjab, India
3 Department of Pharmacy, Chandigarh Pharmacy College, Chandigarh Group of Colleges, Jhanjeri,
Mohali, Punjab, India

Abstract

This prospective, single-blind, randomized study aims to assess the hemodynamic
parameters, onset time, and ease of intubation using succinylcholine and rocuronium
during general anesthesia. Before induction, patients received premedication with
appropriate doses of anticholinergic drugs, anxiolytics, and antiemetics. Anesthesia
induction involved 1% propofol at 2 mg/kg. Each group consisted of 50 randomly
assigned patients. Succinylcholine and rocuronium were administered intravenously
(1.2 mg/kg dose each) to Group 1 and Group 2, respectively. Intubation was carried
*Corresponding author: out after 60 s, and the intubating conditions were evaluated. The onset times were
Vikrant Abbot noted, and heart rate (HR), oxygen saturation (SpO ), and systolic and diastolic
(vikrantabbot@gmail.com) 2
blood pressure (SBP and DBP) readings were recorded every 1, 3, and 5 min using
Citation: Shakeel H, Sharma A, multimodality monitors. While 49 patients in Group 2 experienced good intubating
Abbot V. Comparison of rocuronium
and succinylcholine: Onset of conditions, all patients in Group 1 met clinically acceptable intubating parameters. The
action, ease of intubation, and onset of drug action in Group 1 was 56.42 ± 1.14 s, and in Group 2, it was 56.36 ± 1.08
hemodynamic parameters during s. After 1 min of intubation, there was a discernible increase in HR, SBP, DBP, and mean
general anesthesia. Innov Med
Omics. 2024;1(1):107-114. arterial pressure in both groups. Furthermore, these changes were hemodynamically
doi: 10.36922/imo.3196 comparable between the two drugs. The study findings suggest that intubation
using succinylcholine and rocuronium can be achieved within 60 s with a bolus
Received: March 18, 2024
Accepted: May 16, 2024 dose of 1.2 mg/kg under good to outstanding conditions. Succinylcholine provided
Published Online: July 2, 2024 better intubating conditions compared to rocuronium, although rocuronium may be
Copyright: © 2024 Author(s). considered where succinylcholine use is contraindicated.
This is an Open-Access article
distributed under the terms of the
Creative Commons Attribution Keywords: Anesthesia; Succinylcholine; Rocuronium; Intubating conditions;
License, permitting distribution, Neuromuscular blockers
and reproduction in any medium,
provided the original work is
properly cited.
Publisher’s Note: AccScience
Publishing remains neutral with 1. Introduction
regard to jurisdictional claims in
published maps and institutional The endotracheal tube is a crucial component of advanced airway management, playing
affiliations. a vital role in promptly and safely securing the airway in critically injured and unwell

Volume 1 Issue 1 (2024) 107 doi: 10.36922/imo.3196