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Innovative Medicines & Omics Vitamin D deficiency and cherry angiomas

Vitamin D represents a significant disturbance in vascular Availability of data
homeostasis, which may have contributed to the abrupt
onset of multiple cherry angiomas. While the exact All data utilized in this manuscript can be made available
molecular pathways remain to be fully elucidated, this case upon reasonable request. Specifically, anonymized patient
underscores the importance of evaluating Vitamin D status data and associated laboratory findings can be provided in
in patients presenting with unexplained vascular lesions. compliance with ethical guidelines.
Further research is warranted to validate this hypothesis References
and to investigate therapeutic strategies targeting Vitamin D
pathways as a means to prevent or manage such conditions. 1. Fukuma Y, Ishida M, Yasuda E, et al. Intravascular large
B cell lymphoma diagnosed by skin biopsy from cherry
Acknowledgments angioma: A case report. Mol Clin Oncol. 2024;21(5):87.
The first author of the present study, Maher Monir Akl, doi: 10.3892/mco.2024.2785
with the concurrence of the second author, Amr Ahmed, 2. Sadeghzadeh-Bazargan A, Shafiei M, Atefi N, et al.
would like to express his appreciation to various individuals Evaluation and comparison of the efficacy and safety of
and groups as follows: I extend my deepest gratitude to cryotherapy and electrosurgery in the treatment of sebaceous
all warriors of disease across the globe, whose resilience hyperplasia, seborrheic keratosis, cherry angioma, and skin
inspires every scientific effort to enhance their quality of tag: A blinded randomized clinical trial study. Health Sci
life. I dedicate this work to my mother, whose boundless Rep. 2024;7(11):e70154.
support has been my strength, and to my life partner, doi: 10.1002/hsr2.70154
whose encouragement, pride, and unwavering belief in my 3. Aliashrafi S, Ebrahimi-Mameghani M. 7: A systematic
potential have fueled my journey, even when the true value review on vitamin d and angiogenesis. BMJ Open.
of my contributions was yet unseen. Together, you have 2017;7(Suppl 1):bmjopen-2016-015415.7.
given me the courage to pursue knowledge relentlessly,
with the hope of crafting solutions that may 1 day bring doi: 10.1136/bmjopen-2016-015415
comfort and healing to those who need it most. 4. Barrea L, Savanelli MC, Di Somma C, et al. Vitamin D and
its role in psoriasis: An overview of the dermatologist and
Funding nutritionist. Rev Endocr Metab Disord. 2017;18(2):195-205.
None. doi: 10.1007/s11154-017-9411-6
Conflict of interest 5. Kim DH, Meza CA, Clarke H, Kim JS, Hickner RC. Vitamin
D and endothelial function. Nutrients. 2020;12(2):575.
The authors declare that there are no conflicts of interest. doi: 10.3390/nu12020575
Author contributions 6. Grundmann M, Haidar M, Placzko S, et al. Vitamin D
improves the angiogenic properties of endothelial progenitor
Conceptualization: All authors cells. Am J Physiol. 2012;303(9):C954-C962.
Investigation: All authors
Methodology: All authors doi: 10.1152/ajpcell.00030.2012
Writing – original draft: All authors 7. Pál É, Ungvári Z, Benyó Z, Várbíró S. Role of
Writing – review & drafting: All authors Vitamin D deficiency in the pathogenesis of cardiovascular
and cerebrovascular diseases. Nutrients. 2023;15:334.
Ethics approval and consent to participate doi: 10.3390/nu15020334

This case was conducted in accordance with the Declaration 8. Song YS, Jamali N, Sorenson CM, Sheibani N. Vitamin D
of Helsinki and meets the CARE guidelines. Informed receptor expression limits the angiogenic and inflammatory
consent was obtained from the patient for follow-up, properties of retinal endothelial cells. Cells. 2023;12:335.
including permission for publication of all photographs, doi: 10.3390/cells12020335
laboratory, and images herein.
9. Wimalawansa SJ. Vitamin D deficiency: Effects on oxidative
Consent for publication stress, epigenetics, gene regulation, and aging. Biology.
2019;8(2):30.
Before taking this case, information was given to the patient,
and informed consent was obtained from the patient for doi: 10.3390/biology8020030
follow-up and consent to share the investigations, figures, 10. Roffe-Vazquez DN, Huerta-Delgado AS, Castillo EC, et al.
and any required data. Correlation of Vitamin D with inflammatory cytokines,

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