Page 119 - IMO-2-2

Innovative Medicines & Omics

CASE REPORT
Severe Vitamin D deficiency as a potential

contributor to cherry angiomas: A case study
and novel hypothesis

Maher Monir Akl * and Amr Ahmed 2
1
1 Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt
2 Department of Public Health, Riyadh First Health Cluster, Ministry of Health, Saudi Arabia

Abstract
Cherry angiomas are common benign vascular lesions with a poorly understood
underlying pathogenesis. While factors such as aging, hormonal changes, and
oxidative stress have been implicated, this case introduces a novel hypothesis linking
severe Vitamin D deficiency to the development of cherry angiomas. We report the
case of a 27-year-old Arab female with no medical, genetic, or familial predisposition to
cherry angiomas. The patient presented with multiple asymptomatic, erythematous,
dome-shaped lesions localized to the breast and neck regions. Comprehensive
laboratory evaluations were unremarkable except for severe Vitamin D deficiency,
with a serum level of 3 ng/mL (normal: 30 – 100 ng/mL). Vitamin D deficiency is
known to disrupt endothelial function, increase oxidative stress, and upregulate pro-
angiogenic mediators such as vascular endothelial growth factor. These molecular
disturbances may promote capillary proliferation and vascular instability, providing
*Corresponding author: a plausible mechanism for the sudden onset of cherry angiomas in this patient.
Maher Monir Akl This case highlights the importance of Vitamin D in vascular health and proposes
(maherakl555@gmail.com) a potential link between its deficiency and the pathogenesis of cherry angiomas.
Citation: Akl MM, Ahmed A. Further research is warranted to explore this relationship and elucidate the
Severe Vitamin D deficiency as underlying molecular mechanisms, which may offer new insights into the prevention
a potential contributor to cherry
angiomas: A case study and novel and management of cherry angiomas in patients with Vitamin D deficiency.
hypothesis. Innov Med Omics.
2025;2(2):113-117.
doi: 10.36922/imo.8087 Keywords: Cherry angiomas; Vitamin D deficiency; Angiogenesis; Endothelial
dysfunction; Dermatology
Received: December 20, 2024
Revised: January 8, 2025
Accepted: January 13, 2025
Published online: January 24,
2025 1. Background
Copyright: © 2025 Author(s).
This is an Open-Access article Cherry angiomas are common benign vascular skin lesions characterized by clusters
distributed under the terms of the of dilated capillaries that form red, dome-shaped papules. Furthermore, referred
Creative Commons Attribution to as senile angiomas due to their increasing prevalence with age, they can occur at
License, permitting distribution,
and reproduction in any medium, any stage of life. Histologically, cherry angiomas result from capillary proliferation in
provided the original work is the upper dermis, producing their characteristic erythematous appearance. While
1
properly cited. the exact pathophysiology of cherry angiomas remains incompletely understood, it
Publisher’s Note: AccScience is hypothesized that hormonal changes, genetic predisposition, oxidative stress, and
Publishing remains neutral with vascular aging play significant roles. From a clinical perspective, cherry angiomas are
regard to jurisdictional claims in
published maps and institutional typically asymptomatic and do not require intervention. However, therapeutic options
affiliations. such as laser therapy, cryotherapy, electrocauterization, or excision may be considered

Volume 2 Issue 2 (2025) 113 doi: 10.36922/imo.8087