Page 117 - IMO-2-2
P. 117
Innovative Medicines & Omics Modeling Aurora-B kinase inhibitors
Drosophila Aurora kinase is oncogenic and amplified in doi: 10.1002/cm.20039
human colorectal cancers. EMBO J. 1998;17:3052-3065.
14. Tang A, Gao K, Chu L, Zhang R, Yang J, Zheng J. Aurora
doi: 10.1093/emboj/17.11.3052 kinases: Novel therapy targets in cancers. Oncotarget.
2017;8(14):23937-23954.
3. Mahajan M, Sarkar A, Mondal S. Cell cycle protein BORA is
associated with colorectal cancer progression by AURORA- doi: 10.18632/oncotarget.14893
PLK1 cascades: A bioinformatics analysis. J Cell Commun 15. Jacobsen A, Bosch LJW, Kemp SRM, et al. Aurora kinase A
Signal. 2023;17:773-791.
(AURKA) interaction with Wnt and Ras-MAPK signalling
doi: 10.1007/s12079-022-00719-6 pathways in colorectal cancer. Sci Rep. 2018;8:7522.
4. Azeez KRA, Chatterjee S, Yu C, Golub TR, Sobott F, doi: 10.1038/s41598-018-24982-z
Elkins JM. Structural mechanism of synergistic activation 16. Kanagasabai T, Venkatesan T, Natarajan U, et al. Regulation
of Aurora kinase B/C by phosphorylated INCENP. Nat of cell cycle by MDM2 in prostate cancer cells through
Commun. 2019;10(1):3166. Aurora Kinase-B and p21WAF1/CIP1 mediated pathways.
doi: 10.1038/s41467-019-11085-0 Cell Signal. 2020;66:109435.
5. Nguyen AL, Schindler K. Specialize and divide (Twice): doi: 10.1016/j.cellsig.2019.109435
Functions of three aurora kinase homologs in mammalian 17. Samimi H, Haghpanah V, Irani S, et al. Transcript-level
oocyte meiotic maturation. Trends Genet. 2017;33(5):349-363.
regulation of MALAT1-mediated cell cycle and apoptosis
doi: 10.1016/j.tig.2017.03.005 genes using dual MEK/Aurora kinase inhibitor “BI-847325”
on anaplastic thyroid carcinoma. DARU J Pharm Sci.
6. Marumoto T, Zhang D, Saya H. Aurora-A-a guardian of 2019;27(1):1-7.
poles. Nat Rev Cancer. 2005;5(1):42-50.
doi: 10.1007/s40199-018-0231-3
doi: 10.1038/nrc1526
18. Noor S, Choudhury A, Raza A, et al. Probing baicalin as
7. Carmena M, Earnshaw WC. The cellular geography of
aurora kinases. Nat Rev Mol Cell Biol. 2003;4:842-854. potential inhibitor of Aurora kinase B: A step towards lung
cancer therapy. Int J Biol Macromol. 2024;258:128813.
doi: 10.1038/nrm1245
doi: 10.1016/j.ijbiomac.2023.128813
8. Dutertre S, Descamps S, Prigent C. On the role of aurora-A 19. Huang D, Huang Y, Huang Z, Weng J, Zhang S, Gu W.
in centrosome function. Oncogene. 2002;21(40):6175-6183.
Relation of AURKB over-expression to low survival rate in
doi: 10.1038/sj.onc.1205775 BCRA and reversine-modulated Aurora-B kinase in breast
cancer cell lines. Cancer Cell Int. 2019;19:166.
9. Tsai MY, Wiese C, Cao K, et al. A ran signalling pathway
mediated by the mitotic kinase Aurora A in spindle assembly. doi: 10.1186/s12935-019-0885-z
Nat Cell Biol. 2003;5(3):242-248.
20. Morahan BJ, Abrie C, Al-Hasani K, et al. Human aurora
doi: 10.1038/ncb936 kinase inhibitor hesperadin reveals epistatic interaction
between plasmodium falciparum PfArk1 and PfNek1
10. Murata-Hori M, Tatsuka M, Wang YL. Probing the dynamics
and functions of Aurora-B kinase in living cells during kinases. Commun Biol. 2020;3(1):701.
mitosis and cytokinesis. Mol Biol Cell. 2002;13(4):1099-1108. doi: 10.1038/s42003-020-01424-z
doi: 10.1091/mbc.01-09-0467 21. Kollareddy M, Zheleva D, Džubák P, et al. Identification
and characterization of drug resistance mechanisms in
11. Kimura M, Matsuda Y, Yoshioka T, Sumi N, Okano Y.
Identification and characterization of STK12/Aik2: A cancer cells against Aurora kinase inhibitors CYC116 and
human gene related to aurora of Drosophila and yeast IPL1. ZM447439. bioRxiv. 2020.
Cytogenet Cell Genet. 1998;82(3-4):147-152. doi: 10.1101/2020.08.26.268128
doi: 10.1159/000015089 22. Martens S, Goossens V, Devisscher L, et al. RIPK1-dependent
cell death: A novel target of the Aurora kinase inhibitor
12. Gassmann R, Carvalho A, Henzing AJ, et al. Borealin: A
novel chromosomal passenger required for stability of the Tozasertib (VX-680). Cell Death Dis. 2018;9(2):211.
bipolar mitotic spindle. J Cell Biol. 2004;166(2):179-191. doi: 10.1038/s41419-017-0245-7
doi: 10.1083/jcb.200404001 23. Ajay Kumar TV, Anand SAA, Loganathan C, Saravanan K,
13. Sasai K, Katayama H, Stenoien DL, et al. Aurora-C kinase Kabilan S, Parthasarathy V. Design, 3D QSAR modeling and
is a novel chromosomal passenger protein that can docking of TGF-β type I inhibitors to target cancer. Comput
complement Aurora-B kinase function in mitotic cells. Cell Biol Chem. 2018;76:232-244.
Motil Cytoskeleton. 2004;59(4):249-263. doi: 10.1016/j.compbiolchem.2018.07.011
Volume 2 Issue 2 (2025) 111 doi: 10.36922/imo.6547

