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Innovative Medicines & Omics                              MSC exosomes for digestive tumors: Bench to bedside



               cancer cells. Sci Rep. 2024;14:17812.              doi: 10.1002/jcp.28747

               doi: 10.1038/s41598-024-68922-6                 45.  Xue C, Gao Y, Li X, et al. Mesenchymal stem cells derived
                                                                  from adipose accelerate the progression of colon cancer by
            36.  Jin R, Zhang B, Zhang X,  et al. Exosomes derived from
               human mesenchymal stem cells confer drug resistance in   inducing a MT-CAFs phenotype via TRPC3/NF-KB axis.
                                                                  Stem Cell Res Ther. 2022;13:335.
               gastric cancer. Cell Cycle. 2015;14(15):2473-2483.
                                                                  doi: 10.1186/s13287-022-03017-5
               doi: 10.1080/15384101.2015.1005530
                                                               46.  Qu M, Li J, Hong Z, Jia F, He Y, Yuan L. The role of human
            37.  Mao J, Liang Z, Zhang B,  et al. UBR2 enriched in p53   umbilical cord mesenchymal stem cells-derived exosomal
               deficient mouse bone marrow mesenchymal stem cell-  microRNA-431-  p in survival and prognosis of colorectal
               exosome promoted gastric cancer progression via Wnt/β-  cancer patients. Mutagenesis. 2022;37:164-171.
               catenin pathway. Stem Cells. 2017;35(11):2267-2279.
                                                                  doi: 10.1093/mutage/geac007
               doi: 10.1002/stem.2702
                                                               47.  Chen HL, Li JJ, Jiang F, Shi WJ, Chang GY. MicroRNA-4461
            38.  Ji R, Lin J, Gu H, Ma J, Fu M, Zhang X. Gastric cancer   derived from bone marrow mesenchymal stem cell
               derived mesenchymal stem cells promote the migration of   exosomes inhibits tumorigenesis by downregulating COPB2
               gastric  cancer  cells  through  miR-374a-5p.  Cell Death Dis.   expression in colorectal cancer. Biosci Biotechnol Biochem.
               2022;18:918.
                                                                  2019;84:338-346.
               doi: 10.2174/1574888X18666221124145847
                                                                  doi: 10.1080/09168451.2019.1677452
            39.  Ma M, Chen S, Liu Z,  et al. miRNA-221 of exosomes   48.  Pishavar  E,  Yazdian-Robati  R,  Abnous  K,  et al.  Aptamer-
               originating from bone marrow mesenchymal stem cells   functionalized mesenchymal stem cells-derived exosomes
               promotes oncogenic activity in gastric cancer. Onco Targets   for targeted delivery of SN38 to colon cancer cells. Iran J
               Ther. 2017;10:4161-4171.
                                                                  Basic Med Sci. 2023;26:388-394.
               doi: 10.2147/OTT.S143315                           doi: 10.22038/IJBMS.2023.68039.14873
            40.  Qi J, Zhou Y, Jiao Z, et al. Exosomes derived from human   49.  Bagheri E, Abnous K, Farzad SA, Taghdisi SM, Ramezani M,
               bone marrow mesenchymal stem cells promote tumor   Alibolandi M. Targeted doxorubicin-loaded mesenchymal
               growth through hedgehog signaling pathway.  Cell Physiol   stem cells-derived exosomes as a versatile platform for
               Biochem. 2017;42(6):2242-2254.                     fighting against colorectal cancer. Life Sci. 2020;261:118369.
               doi: 10.1159/000479998                             doi: 10.1016/j.lfs.2020.118369
            41.  Mansourabadi  AH,  Aghamajidi  A,  Faraji  F,  et al.   50.  Han S, Li G, Jia M, et al. Delivery of anti-miRNA-221 for
               Mesenchymal stem cells-derived exosomes inhibit the   colorectal carcinoma therapy using modified cord blood
               expression of Aquaporin-5 and EGFR in HCT-116 human   mesenchymal stem cells-derived exosomes.  Front Mol
               colorectal carcinoma cell line. BMC Mol Cell Biol. 2022;23:40.  Biosci. 2021;8:743013.
               doi: 10.1186/s12860-022-00439-0                    doi: 10.3389/fmolb.2021.743013
            42.  Jahangiri B, Khalaj-Kondori M, Asadollahi E, Purrafee   51.  Ding Y, Mei W, Zheng Z,  et al. Exosomes secreted from
               Dizaj L, Sadeghizadeh M. MSC-Derived exosomes suppress   human umbilical cord mesenchymal stem cells promote
               colorectal cancer cell proliferation and metastasis via miR-  pancreatic ductal adenocarcinoma growth by transferring
               100/mTOR/miR-143 pathway. Int J Pharm. 2022;627:122214.  miR-100-5p. Tissue Cell. 2021;73:101623.
               doi: 10.1016/j.ijpharm.2022.122214                 doi: 10.1016/j.tice.2021.101623
            43.  Chen J, Li Z, Yue C,  et al. Human umbilical cord   52.  Ding Y, Cao F, Sun H, et al. Exosomes derived from human
               mesenchymal stem cell-derived exosomes carrying miR-  umbilical cord mesenchymal stromal cells deliver exogenous
               1827 downregulate SUCNR1 to inhibit macrophage     miR-145-5p to inhibit pancreatic ductal adenocarcinoma
               M2 polarization and prevent colorectal liver metastasis.   progression. Cancer Lett. 2018;442:351-361.
               Apoptosis. 2023;28:549-565.
                                                                  doi: 10.1016/j.canlet.2018.10.039
               doi: 10.1007/s10495-022-01798-x
                                                               53.  Shang S, Wang J, Chen S, et al. Exosomal miRNA-1231 derived
            44.  Xu Y, Shen L, Li F, Yang J, Wan X, Ouyang M. microRNA-  from bone marrow mesenchymal stem cells inhibits the
               16-5p-containing exosomes derived from bone marrow-  activity of pancreatic cancer. Cancer Med. 2019;8:7728-7740.
               derived mesenchymal stem cells inhibit proliferation,
               migration, and invasion, while promoting apoptosis of      doi: 10.1002/cam4.2633
               colorectal cancer cells by downregulating ITGA2.  J  Cell   54.  Sherman MH, Beatty GL. Tumor microenvironment in
               Physiol. 2019;234:21380-21394.                     pancreatic cancer pathogenesis and therapeutic resistance.


            Volume 2 Issue 3 (2025)                         11                          doi: 10.36922/IMO025210025
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