Page 16 - IMO-2-3
P. 16
Innovative Medicines & Omics MSC exosomes for digestive tumors: Bench to bedside
cell-derived exosomes as communicators in drug resistance doi: 10.18632/aging.205025
in multiple myeloma cells. Blood. 2014;124:555-566.
26. Wang Y, Wang B, Xiao S, et al. miR-125a/b inhibits tumor-
doi: 10.1182/blood-2014-03-562439 associated macrophages mediated in cancer stem cells of
hepatocellular carcinoma by targeting CD90. J Cell Biochem.
17. Deng M, Yuan H, Liu S, et al. Exosome-transmitted
LINC00461 promotes multiple myeloma cell proliferation 2018;120:3046-3055.
and suppresses apoptosis by modulating microRNA/BCL-2 doi: 10.1002/jcb.27436
expression. Cytotherapy. 2019;21:96-106.
27. Lou G, Chen L, Xia C, et al. MiR-199a-modified exosomes
doi: 10.1016/j.jcyt.2018.10.006 from adipose tissue-derived mesenchymal stem cells
improve hepatocellular carcinoma chemosensitivity through
18. Zhang F, Lu Y, Wang M, et al. Exosomes derived from
human bone marrow mesenchymal stem cells transfer miR- mTOR pathway. Exp Clin Cancer. 2020;39:4.
222-3p to suppress acute myeloid leukemia cell proliferation doi: 10.1186/s13046-019-1512-5
by targeting IRF2/INPP4B. Mol Cell Probes. 2020;51:101513.
28. Li YH, Lv MF, Lu M, Bi JP. Bone marrow mesenchymal stem
doi: 10.1016/j.mcp.2020.101513 cell-derived exosomal MiR-338-3p represses progression
of hepatocellular carcinoma by targeting ETS1. J Biol Regul
19. Liu X, Li Y, Zhou W, et al. Chinese multidisciplinary
expert consensus on immune checkpoint inhibitor-based Homeost Agents. 2021;35:617-627.
combination therapy for hepatocellular carcinoma (2023 doi: 10.23812/20-638-a
edition). Liver Cancer. 2024;13:355-375.
29. Dong B, Liu W, Fan W, Pan J. Exosomal miR-374c-5p derived
doi: 10.1159/000535496 from mesenchymal stem cells suppresses epithelial-mesenchymal
transition of hepatocellular carcinoma via the LIMK1-Wnt/β-
20. Ma YS, Liu JB, Lin L, et al. Exosomal microRNA-15a from
mesenchymal stem cells impedes hepatocellular carcinoma catenin axis. Environ Toxicol. 2023;38:1038-1052.
progression via downregulation of SALL4. Cell Death doi: 10.1002/tox.23746
Discov. 2021;7:224.
30. Liang L, Zhao L, Wang Y, Wang Y. Treatment for
doi: 10.1038/s41420-021-00611-z hepatocellular carcinoma is enhanced when norcantharidin
is encapsulated in exosomes derived from bone marrow
21. ElBadre HM, El-Deek SEM, Ramadan HK, et al. Potential
role of human umbilical cord stem cells-derived exosomes mesenchymal stem cells. Mol Pharm. 2021;18:1003-1013.
as novel molecular inhibitors of hepatocellular carcinoma doi: 10.1021/acs.molpharmaceut.0c00976
growth. Apoptosis. 2023;28:1346-1356.
31. Li H, Yang C, Shi Y, Zhao L. Exosomes derived from
doi: 10.1007/s10495-023-01863-z siRNA against GRP78 modified bone-marrow-derived
mesenchymal stem cells suppress Sorafenib resistance in
22. Xu Y, Lai Y, Cao L, et al. Human umbilical cord mesenchymal
stem cells-derived exosomal microRNA-451a represses hepatocellular carcinoma. J Nanobiotechnology. 2018;16:103.
epithelial-mesenchymal transition of hepatocellular doi: 10.1186/s12951-018-0429-z
carcinoma cells by inhibiting ADAM10. RNA Biol. 32. Liu G, Cenador MBG, Si S, Wang H, Yang Q. Influences of
2020;18:1408-1423.
umbilical cord mesenchymal stem cells and their exosomes
doi: 10.1080/15476286.2020.1851540 on tumor cell phenotypes. Am J Cancer Res. 2024;13:
6270-6279.
23. Xu G, Ban K, Mu H, Wang B. Human umbilical cord
mesenchymal stem cells-derived exosomal lncrna fam99b 33. Mirzaei S, Gholami M, Aghdaei HA, et al. Exosome-
represses hepatocellular carcinoma cell malignancy. Mol mediated miR-200a delivery into TGF-β-treated AGS
Biotechnol. 2023;66:1389-1401. cells abolished epithelial-mesenchymal transition with
normalization of ZEB1, vimentin and Snail1 expression.
doi: 10.1007/s12033-023-00795-y
Environ Res. 2023;231:116115.
24. Gu H, Yu C, Wang H, et al. Mesenchymal stem cell-derived
exosomes block malignant behaviors of hepatocellular doi: 10.1016/j.envres.2023.116115
carcinoma stem cells through a lncRNA C5orf66-AS1/ 34. Chang L, Gao H, Wang L, et al. Exosomes derived from
microRNA-127-3p/DUSP1/ERK axis. Hum Cell. miR-1228 overexpressing bone marrow-mesenchymal stem
2021;34:1812-1829. cells promote growth of gastric cancer cells. Aging (Albany
NY). 2021;13:11808-11821.
doi: 10.1007/s13577-021-00599-9
doi: 10.18632/aging.202878
25. Li M, Zhai P, Mu X, et al. Hypoxic BMSC-derived exosomal
miR-652-3p promotes proliferation and metastasis of 35. Sun W, Chen W, Li N, et al. Oxaliplatin-induced upregulation
hepatocarcinoma cancer cells via targeting TNRC6A. Aging of exosomal miR-424-3p derived from human bone marrow
(Albany NY). 2023;15:12780-12793. mesenchymal stem cells attenuates progression of gastric
Volume 2 Issue 3 (2025) 10 doi: 10.36922/IMO025210025

