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39 INNOSC Theranostics and Pharmacological Sciences, 2023, Vol. 6, No. 1 Hariharan

Table 1. (Continued)
Study First author Region Country Study design Sample Study Criteria Mean Quality
no. and year size participants and age (in of
cut ‑ off years) evidence
10 Gordeuk et al. America USA Prospective 160 Participants with TRJV 13 High
2011 [27] SCA who had and 2.5
clinical evaluation,
echocardiography
and 6 - min walk
test performed at
steady - state
11 Gore et al. SEAR India Cross - 38 Children with SCA TRJV NA High
2018 [28] sectional and 2.5
12 Hagar et al. America USA Retrospective 61 Children with SCA TRJV 12.7 High
2007 [29] and 2.5
13 Hebson et al. America USA Retrospective 630 Children with SCA TRJV 11.7 High
2015 [30] and 2.5
14 Jesus Rojas America USA Prospective 29 Children with SCA TRJV NA High
et al. 2018 [31] and 2.5
15 Lamina et al. Africa Nigeria Cross - 200 SCA children TRJV 6.6 Low
2019 [32] sectional aged 1 to 12 and 2.5
years attending
the sickle cell
clinic who were in
steady state
16 Liem et al. America USA Prospective 51 Children with SCA TRJV 14 High
2007 [33] and 2.5
17 Liem et al. America USA Prospective 78 Children with SCA TRJV 14.3 High
2009 [34] and 2.5
18 Minniti et al. America USA Prospective 310 Children and TRJV 13 High
2009 [35] adolescents with and 2.5
SCA
19 Molavi et al. EMR Iran Retrospective 70 Children with SCA TRJV NA High
2014 [36] and 2.5
20 Mondal et al. America USA Retrospective 20 Children with SCA TRJV 10.4 High
2018 [37] and 2.5
21 Nelson et al. America USA Prospective 53 SCA patients TRJV 12.4 High
2007 [38] under the age of and 2.5
10 years
22 Nouraie et al. America USA Prospective 469 Children and TRJV 12 High
2020 [39] adolescents with and 2.7
SCA
23 Onalo et al. Africa Nigeria Cross - 176 Children with SCA TRJV 10.4 Low
2020 [40] sectional and 2.5
24 Onyekwere America USA Cross - 52 Children and TRJV 16.1 High
et al. 2008 [41] sectional adolescents with and 2.5
SCA
25 Pashankar America USA Prospective 62 Children with SCA TRJV 13.5 High
et al. 2008 [42] and 2.5

(Cont’d...)

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