Page 38 - ITPS-7-2
P. 38

INNOSC Theranostics and
            Pharmacological Sciences                                                         Mitochondria and aging



               disease. Nat Rev Genet. 2015;16(9):530-542.        at fragile sites of mitochondrial DNA.  Nucleic Acids Res.
                                                                  2009;37(7):2327-2335.
               doi: 10.1038/nrg3966
                                                                  doi: 10.1093/nar/gkp091
            58.  Filograna R, Koolmeister C, Upadhyay M, et al. Modulation
               of mtDNA copy number ameliorates the pathological   69.  Williams SL, Huang J, Edwards YJK,  et al. The mtDNA
               consequences of a heteroplasmic mtDNA mutation in the   mutation spectrum of the progeroid Polg mutator mouse
               mouse. Sci Adv. 2019;5(4):eaav9824.                includes abundant control region multimers.  Cell Metab.
                                                                  2010;12(6):675-682.
               doi: 10.1126/sciadv.aav9824
                                                                  doi: 10.1016/j.cmet.2010.11.012
            59.  Mancuso M, Orsucci D, Angelini C, et al. The m. 3243A> G
               mitochondrial DNA mutation and related phenotypes.   70.  Harman  D.  Aging:  A  theory  based  on  free  radical  and
               A matter of gender? J Neurol. 2014;261:504-510.    radiation chemistry. J Gerontol. 1956;11(3):298-300.
               doi: 10.1007/s00415-013-7225-3                     doi: 10.1093/geronj/11.3.298
            60.  Li D, Liang C, Zhang T,  et al. Pathogenic mitochondrial   71.  Bandy B, Davison AJ. Mitochondrial mutations may increase
               DNA 3243A> G mutation: From genetics to phenotype.   oxidative stress: Implications for carcinogenesis and aging?
               Front Genet. 2022;13:951185.                       Free Radic Biol Med. 1990;8(6):523-539.
               doi: 10.3389/fgene.2022.951185                     doi: 10.1016/0891-5849(90)90152-9
            61.  Goto Y, Nonaka I, Horai S. A mutation in the tRNALeu (UUR)   72.  Hiona A, Leeuwenburgh C. The role of mitochondrial DNA
               gene associated with the MELAS subgroup of mitochondrial   mutations in aging and sarcopenia: Implications for the
               encephalomyopathies. Nature. 1990;348(6302):651-653.  mitochondrial vicious cycle theory of aging. Exp Gerontol.
                                                                  2008;43(1):24-33.
               doi: 10.1038/348651a0
                                                                  doi: 10.1016/j.exger.2007.10.001
            62.  Arbeithuber B, Cremona MA, Hester J, et al. Advanced age
               increases frequencies of de novo mitochondrial mutations   73.  Alexeyev MF, Ledoux SP, Wilson GL. Mitochondrial DNA
               in macaque oocytes and somatic tissues. Proc Natl Acad Sci   and aging. Clin Sci (Lond). 2004;107(4):355-364.
               U S A. 2022;119(15):e2118740119.
                                                                  doi: 10.1042/cs20040148
               doi: 10.1073/pnas.2118740119
                                                               74.  Blagosklonny MV. Aging: Ros or tor. Cell Cycle.
            63.  Cortopassi GA, Arnheim N. Detection of a specific   2008;7(21):3344-3354.
               mitochondrial DNA deletion in tissues of older humans.      doi: 10.4161/cc.7.21.6965
               Nucleic Acids Res. 1990;18(23):6927-6933.
                                                               75.  Cabreiro F, Ackerman D, Doonan R,  et al. Increased life
               doi: 10.1093/nar/18.23.6927
                                                                  span from overexpression of superoxide dismutase in
            64.  Pikó L, Hougham AJ, Bulpitt KJ. Studies of sequence   Caenorhabditis elegans is not caused by decreased oxidative
               heterogeneity of mitochondrial DNA from rat and mouse   damage. Free Radic Biol Med. 2011;51(8):1575-1582.
               tissues: Evidence for an increased frequency of deletions/     doi: 10.1016/j.freeradbiomed.2011.07.020
               additions with aging. Mech Ageing Dev. 1988;43(3):279-293.
                                                               76.  Gems D, Doonan R. Antioxidant defense and aging in C.
               doi: 10.1016/0047-6374(88)90037-1
                                                                  elegans: Is the oxidative damage theory of aging wrong? Cell
            65.  Khrapko K, Vijg J. Mitochondrial DNA mutations and   Cycle. 2009;8(11):1681-1687.
               aging: Devils in the details? Trends Genet. 2009;25(2):91-98.
                                                                  doi: 10.4161/cc.8.11.8595
               doi: 10.1016/j.tig.2008.11.007
                                                               77.  Koc A, Gasch AP, Rutherford JC, Kim HY, Gladyshev VN.
            66.  Kujoth GC, Hiona A, Pugh TD, et al. Mitochondrial DNA   Methionine sulfoxide reductase regulation of yeast
               mutations,  oxidative stress, and  apoptosis  in  mammalian   lifespan reveals reactive oxygen species-dependent and-
               aging. Science. 2005;309(5733):481-484.            independent components of aging. Proc Natl Acad Sci U S A.
                                                                  2004;101(21):7999-8004.
               doi: 10.1126/science.1112125
                                                                  doi: 10.1073/pnas.0307929101
            67.  Trifunovic A, Wredenberg A, Falkenberg M, et al. Premature
               ageing in mice expressing defective mitochondrial DNA   78.  Lapointe J, Hekimi S. When a theory of aging ages badly.
               polymerase. Nature. 2004;429(6990):417-423.        Cell Mol Life Sci. 2010;67:1-8.
               doi: 10.1038/nature02517                           doi: 10.1007/s00018-009-0138-8
            68.  Bailey LJ, Cluett TJ, Reyes A,  et al. Mice expressing an   79.  Mockett RJ, Sohal BH, Sohal RS. Expression of multiple
               error-prone DNA polymerase in mitochondria display   copies of mitochondrially targeted catalase or genomic
               elevated replication pausing and chromosomal breakage   Mn superoxide dismutase transgenes does not extend the


            Volume 7 Issue 2 (2024)                         16                               doi: 10.36922/itps.1726
   33   34   35   36   37   38   39   40   41   42   43