Page 43 - ITPS-7-2

INNOSC Theranostics and
Pharmacological Sciences Mitochondria and aging

treatment. Antioxidants (Basel). 2020;9(8):700. 179. Díaz-Casado ME, Quiles JL, Barriocanal-Casado E,
et al. The paradox of coenzyme Q10 in aging. Nutrients.
doi: 10.3390/antiox9080700
2019;11(9):2221.
169. Harrington LA, Harley CB. Effect of vitamin E on lifespan
and reproduction in Caenorhabditis elegans. Mech Ageing doi: 10.3390/nu11092221
Dev. 1988;43(1):71-78. 180. Muta‐Takada K, Terada T, Yamanishi H, et al. Coenzyme
doi: 10.1016/0047-6374(88)90098-x Q10 protects against oxidative stress‐induced cell death
and enhances the synthesis of basement membrane
170. Navarro A, Gómez C, Sánchez-Pino MJ, et al. components in dermal and epidermal cells. Biofactors.
Vitamin E at high doses improves survival, neurological 2009;35(5):435-441.
performance, and brain mitochondrial function in aging
male mice. Am J Physiol Regul Integr Comp Physiol. doi: 10.1002/biof.56
2005;289(5):R1392-R1399. 181. Inui M, Ooe M, Fujii K, Matsunaka H, Yoshida M,
doi: 10.1152/ajpregu.00834.2004 Ichihashi M. Mechanisms of inhibitory effects of CoQ10
on UVB-induced wrinkle formation in vitro and in vivo.
171. Schaffer S, Müller WE, Eckert GP. Tocotrienols: Biofactors. 2008;32(1-4):237-243.
Constitutional effects in aging and disease. J Nutr.
2005;135(2):151-154. doi: 10.1002/biof.5520320128
doi: 10.1093/jn/135.2.151 182. Bank G, Kagan D, Madhavi D. Coenzyme Q10: Clinical
update and bioavailability. J Evid Based Complement Altern
172. Collins JJ, Evason K, Kornfeld K. Pharmacology of delayed Med. 2011;16(2):129-137.
aging and extended lifespan of Caenorhabditis elegans. Exp
Gerontol. 2006;41(10):1032-1039. doi: 10.1177/2156587211399438
doi: 10.1016/j.exger.2006.06.038 183. Alcázar-Fabra M, Trevisson E, Brea-Calvo G. Clinical
syndromes associated with Coenzyme Q10 deficiency.
173. Siler-Marsiglio KI, Pan Q, Paiva M, Madorsky I, Essays Biochem. 2018;62(3):377-398.
Khurana NC, Heaton MB. Mitochondrially targeted
vitamin E and vitamin E mitigate ethanol-mediated effects doi: 10.1042/ebc20170107
on cerebellar granule cell antioxidant defense systems. 184. Desbats MA, Lunardi G, Doimo M, Trevisson E, Salviati L.
Brain Res. 2005;1052(2):202-211. Genetic bases and clinical manifestations of coenzyme Q 10
doi: 10.1016/j.brainres.2005.06.030 (CoQ 10) deficiency. J Inherit Metab Dis. 2015;38:145-156.
174. La Fata G, van Vliet N, Barnhoorn S, et al. Vitamin E doi: 10.1007/s10545-014-9749-9
supplementation reduces cellular loss in the brain of a 185. Quiles JL, Ochoa JJ, Huertas JR, Mataix J. Coenzyme Q
premature aging mouse model. J Prev Alzheimers Dis. supplementation protects from age-related DNA double-
2017;4(4):226-235. strand breaks and increases lifespan in rats fed on a PUFA-
doi: 10.14283/jpad.2017.30 rich diet. Exp Gerontol. 2004;39(2):189-194.
175. Beal MF. Mitochondria, oxidative damage, and doi: 10.1016/j.exger.2003.10.002
inflammation in Parkinson’s disease. Ann N Y Acad Sci. 186. Tomasetti M, Alleva R, Collins AR. In vivo supplementation
2003;991(1):120-131. with coenzyme Q10 enhances the recovery of human
doi: 10.1111/j.1749-6632.2003.tb07470.x lymphocytes from oxidative DNA damage. FASEB
J. 2001;15(8):1425-1427.
176. Ayunin Q, Miatmoko A, Soeratri W, Erawati T, Susanto J,
Legowo D. Improving the anti-ageing activity of coenzyme doi: 10.1096/fj.00-0694fje
Q10 through protransfersome-loaded emulgel. Sci 187. Lönnrot K, Alho H, Holm P, Lagerstedt A, Huhtala H. The
Rep. 2022;12(1):906. effects of lifelong ubiquinone Q10 supplementation on the
doi: 10.1038/s41598-021-04708-4 Q9 and Q10 tissue concentrations and life span of male rats
and mice. IUBMB Life. 1998;44(4):727-737.
177. Hidalgo-Gutiérrez A, González-García P, Díaz-Casado ME,
et al. Metabolic targets of coenzyme Q10 in mitochondria. doi: 10.1080/15216549800201772
Antioxidants (Basel). 2021;10(4):520. 188. Asencio C, Rodríguez-Aguilera JC, Ruiz-Ferrer M,
doi: 10.3390/antiox10040520 Vela J, Navas P. Silencing of ubiquinone biosynthesis
genes extends life span in Caenorhabditis elegans. FASEB
178. Acosta MJ, Fonseca LV, Desbats MA, et al. Coenzyme Q
biosynthesis in health and disease. Biochim Biophys Acta. J. 2003;17(9):1135-1137.
2016;1857(8):1079-1085. doi: 10.1096/fj.02-1022fje
doi: 10.1016/j.bbabio.2016.03.036 189. Larsen PL, Clarke CF. Extension of life-span in

Volume 7 Issue 2 (2024) 21 doi: 10.36922/itps.1726