Page 42 - ITPS-7-2
P. 42
INNOSC Theranostics and
Pharmacological Sciences Mitochondria and aging
doi: 10.1177/1535370215581314 doi: 10.1016/0921-8734(92)90030-S
147. Phaniendra A, Jestadi DB, Periyasamy L. Free radicals: 158. Siqueira IR, Fochesatto C, de Andrade A, et al. Total
Properties, sources, targets, and their implication in various antioxidant capacity is impaired in different structures
diseases. Indian J Clin Biochem. 2015;30:11-26. from aged rat brain. Int J Dev Neurosci. 2005;23(8):663-671.
doi: 10.1007/s12291-014-0446-0 doi: 10.1016/j.ijdevneu.2005.03.001
148. Frijhoff J, Winyard PG, Zarkovic N, et al. Clinical relevance 159. Akila VP, Harishchandra H, D’souza V, D’souza B. Age
of biomarkers of oxidative stress. Antioxid Redox Signal. related changes in lipid peroxidation and antioxidants in
2015;23(14):1144-1170. elderly people. Indian J Clin Biochem. 2007;22:131-134.
doi: 10.1089/ars.2015.6317 doi: 10.1007/bf02912896
149. Birben E, Sahiner UM, Sackesen C, Erzurum S, Kalayci O. 160. Rizvi SI, Maurya PK. Alterations in antioxidant enzymes
Oxidative stress and antioxidant defense. World Allergy during aging in humans. Mol Biotechnol. 2007;37:58-61.
Organ J. 2012;5:9-19. doi: 10.1007/s12033-007-0048-7
doi: 10.1097/wox.0b013e3182439613 161. Wei YH, Lu CY, Lee HC, Pang CY, Ma YS. Oxidative damage
150. Wu JQ, Kosten TR, Zhang XY. Free radicals, and mutation to mitochondrial dna and age‐dependent
antioxidant defense systems, and schizophrenia. Prog decline of mitochondrial respiratory function. Ann N Y
Neuropsychopharmacol Biol Psychiatry. 2013;46:200-206. Acad Sci. 1998;854(1):155-170.
doi: 10.1016/j.pnpbp.2013.02.015 doi: 10.1111/j.1749-6632.1998.tb09899.x
162. Ashrafian H, Czibik G, Bellahcene M, et al. Fumarate is
151. Pisoschi AM, Pop A. The role of antioxidants in the
chemistry of oxidative stress: A review. Eur J Med Chem. cardioprotective via activation of the Nrf2 antioxidant
2015;97:55-74. pathway. Cell Metab. 2012;15(3):361-371.
doi: 10.1016/j.cmet.2012.01.017
doi: 10.1016/j.ejmech.2015.04.040
163. Ryan TA, Hooftman A, Rehill AM, et al. Dimethyl fumarate
152. Lü JM, Lin PH, Yao Q, Chen C. Chemical and molecular
mechanisms of antioxidants: Experimental approaches and and 4-octyl itaconate are anticoagulants that suppress tissue
model systems. J Cell Mol Med. 2010;14(4):840-860. factor in macrophages via inhibition of type I interferon.
Nat Commun. 2023;14(1):3513.
doi: 10.1111/j.1582-4934.2009.00897.x
doi: 10.1038/s41467-023-39174-1
153. Skrzydlewska E, Augustyniak A, Michalak K, 164. Ellrichmann G, Petrasch-Parwez E, Lee DH, et al. Efficacy
Farbiszewski R. Green tea supplementation in rats of of fumaric acid esters in the R6/2 and YAC128 models of
different ages mitigates ethanol-induced changes in brain Huntington’s disease. PLoS One. 2011;6(1):e16172.
antioxidant abilities. Alcohol. 2005;37(2):89-98.
doi: 10.1371/journal.pone.0016172
doi: 10.1016/j.alcohol.2005.12.003
165. Hoyle C, Green JP, Allan SM, Brough D, Lemarchand E.
154. Sawada M, Carlson JC. Changes in superoxide radical Itaconate and fumarate derivatives inhibit priming and
and lipid peroxide formation in the brain, heart and activation of the canonical NLRP3 inflammasome in
liver during the lifetime of the rat. Mech Ageing Dev. macrophages. Immunology. 2022;165(4):460-480.
1987;41(1-2):125-137.
doi: 10.1111/imm.13454
doi: 10.1016/0047-6374(87)90057-1
166. Sharkus R, Thakkar R, Kolson DL, Constantinescu CS.
155. Rao G, Xia E, Richardson A. Effect of age on the expression Dimethyl fumarate as potential treatment for Alzheimer’s
of antioxidant enzymes in male Fischer F344 rats. Mech disease: Rationale and clinical trial design. Biomedicines.
Ageing Dev. 1990;53(1):49-60. 2023;11(5):1387.
doi: 10.1016/0047-6374(90)90033-c doi: 10.3390/biomedicines11051387
156. Murali G, Panneerselvam KS, Panneerselvam C. Age- 167. Scuderi SA, Ardizzone A, Paterniti I, Esposito E,
associated alterations of lipofuscin, membrane-bound Campolo M. Antioxidant and anti-inflammatory effect
ATPases and intracellular calcium in cortex, striatum and of Nrf2 inducer dimethyl fumarate in neurodegenerative
hippocampus of rat brain: Protective role of glutathione diseases. Antioxidants (Basel). 2020;9(7):630.
monoester. Int J Dev Neurosci. 2008;26(2):211-215.
doi: 10.3390/antiox9070630
doi: 10.1016/j.ijdevneu.2007.12.004
168. Rosito M, Testi C, Parisi G, Cortese B, Baiocco P, Di
157. Harman D. Free radical theory of aging. Mutat Res. Angelantonio S. Exploring the use of dimethyl fumarate
1992;275(3-6):257-266. as microglia modulator for neurodegenerative diseases
Volume 7 Issue 2 (2024) 20 doi: 10.36922/itps.1726

