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INNOSC Theranostics and
Pharmacological Sciences Mitochondria and aging

translocation. BMC Biol. 2018;16(1):11. 112. Tran HC, Van Aken O. Mitochondrial unfolded protein-
related responses across kingdoms: Similar problems,
doi: 10.1186/s12915-017-0474-3
different regulators. Mitochondrion. 2020;53:166-177.
102. Scherer PE, Krieg UC, Hwang ST, Vestweber D, Schatz G.
A precursor protein partly translocated into yeast doi: 10.1016/j.mito.2020.05.009
mitochondria is bound to a 70 kd mitochondrial stress 113. Wrobel L, Topf U, Bragoszewski P, et al. Mistargeted
protein. EMBO J. 1990;9(13):4315-4322. mitochondrial proteins activate a proteostatic response in
the cytosol. Nature. 2015;524(7566):485-488.
doi: 10.1002/j.1460-2075.1990.tb07880.x
doi: 10.1016/j.nbd.2009.08.009
103. Ostermann J, Voos W, Kang PJ, Craig EA, Neupert W,
Pfanner N. Precursor proteins in transit through 114. Benedetti C, Haynes CM, Yang Y, Harding HP, Ron D.
mitochondrial contact sites interact with hsp70 in the Ubiquitin-like protein 5 positively regulates chaperone
matrix. FEBS Lett. 1990;277(1-2):281-284. gene expression in the mitochondrial unfolded protein
response. Genetics. 2006;174(1):229-239.
doi: 10.1016/0014-5793(90)80865-g
doi: 10.1534/genetics.106.061580
104. Liu Q, Krzewska J, Liberek K, Craig EA. Mitochondrial
Hsp70 Ssc1: Role in protein folding. J Biol Chem. 115. Jovaisaite V, Mouchiroud L, Auwerx J. The mitochondrial
2001;276(9):6112-6118. unfolded protein response, a conserved stress response
pathway with implications in health and disease. J Exp Biol.
doi: 10.1074/jbc.m009519200 2014;217(1):137-143.
105. Pimenta de Castro I, Costa A, Lam D, et al. Genetic doi: 10.1242/jeb.090738
analysis of mitochondrial protein misfolding in Drosophila
melanogaster. Cell Death Differ. 2012;19(8):1308-1316. 116. Muñoz-Carvajal F, Sanhueza M. The mitochondrial
unfolded protein response: A hinge between healthy and
doi: 10.1038/cdd.2012.5 pathological aging. Front Aging Neurosci. 2020;12:581849.
106. Nargund AM, Pellegrino MW, Fiorese CJ, Baker BM, doi: 10.3389/fnagi.2020.581849
Haynes CM. Mitochondrial import efficiency of ATFS-1
regulates mitochondrial UPR activation. Science. 117. Mouchiroud L, Houtkooper RH, Moullan N, et al. The
2012;337(6094):587-590. NAD+/sirtuin pathway modulates longevity through
activation of mitochondrial UPR and FOXO signaling. Cell.
doi: 10.1126/science.1223560 2013;154(2):430-441.
107. Qureshi MA, Haynes CM, Pellegrino M. The mitochondrial doi: 10.1016/j.cell.2013.06.016
unfolded protein response: Signaling from the powerhouse.
J Biol Chem. 2017;292(33):13500-13506. 118. Dillin A, Hsu AL, Arantes-Oliveira N, et al. Rates of
behavior and aging specified by mitochondrial function
doi: 10.1074/jbc.r117.791061 during development. Science. 2002;298(5602):2398-2401.
108. Runkel ED, Liu S, Baumeister R, Schulze E. Surveillance- doi: 10.3390/nu11092221
activated defenses block the ROS–induced mitochondrial
unfolded protein response. PLoS Genet. 2013;9(3):e1003346. 119. Durieux J, Wolff S, Dillin A. The cell-non-autonomous
nature of electron transport chain-mediated longevity. Cell.
doi: 10.1371/journal.pgen.1003346 2011;144(1):79-91.
109. Fiorese CJ, Schulz AM, Lin YF, Rosin N, Pellegrino MW, doi: 10.1016/j.cell.2010.12.016
Haynes CM. The transcription factor ATF5 mediates
a mammalian mitochondrial UPR. Curr Biol. 120. Han B, Sivaramakrishnan P, Lin CCJ, et al. Microbial genetic
2016;26(15):2037-2043. composition tunes host longevity. Cell. 2017;169(7):1249-
1262.e13.
doi: 10.1016/j.cub.2016.06.002
doi: 10.1016/j.cell.2017.05.036
110. Gao K, Li Y, Hu S, Liu Y. SUMO peptidase ULP-4 regulates
mitochondrial UPR-mediated innate immunity and 121. Wu Z, Senchuk MM, Dues DJ, et al. Mitochondrial
lifespan extension. Elife. 2019;8:e41792. unfolded protein response transcription factor ATFS-1
promotes longevity in a long-lived mitochondrial mutant
doi: 10.7554/elife.41792 through activation of stress response pathways. BMC Biol.
2018;16:147.
111. Haynes CM, Yang Y, Blais SP, Neubert TA, Ron D. The
matrix peptide exporter HAF-1 signals a mitochondrial doi: 10.1186/s12915-018-0615-3
UPR by activating the transcription factor ZC376. 7 in C. 122. Tian Y, Garcia G, Bian Q, et al. Mitochondrial stress
elegans. Mol Cell. 2010;37(4):529-540.
induces chromatin reorganization to promote longevity
doi: 10.1016/j.molcel.2010.01.015 and UPRmt. Cell. 2016;165(5):1197-1208.

Volume 7 Issue 2 (2024) 18 doi: 10.36922/itps.1726