Page 51 - ITPS-8-1

INNOSC Theranostics and
Pharmacological Sciences Ketamine for cocaine use disorder

doi: 10.1016/j.euroneuro.2020.01.001 induced locomotor activity and ketamine pharmacokinetics
in preweanling, adolescent, and adult rats. Eur
96. Dossat AM, Wright KN, Strong CE, Kabbaj M. Behavioral and
biochemical sensitivity to low doses of ketamine: Influence Neuropsychopharmacol. 2019;29(6):740-755.
of estrous cycle in C57BL/6 mice. Neuropharmacology. doi: 10.1016/j.euroneuro.2019.03.013
2018;130:30-41.
106. Chen WC, Wang TS, Chang FY, Chen PA, Chen YC. Age,
doi: 10.1016/j.neuropharm.2017.11.022 dose, and locomotion: Decoding vulnerability to ketamine in
C57BL/6J and BALB/c mice. Biomedicines. 2023;11(7):1821.
97. Highland JN, Farmer CA, Zanos P, et al. Sex-dependent
metabolism of ketamine and (2R,6R)-hydroxynorketamine doi: 10.3390/biomedicines11071821
in mice and humans. J Psychopharmacol (Oxf). 107. Nicolas C, Russell TI, Pierce AF, et al. Incubation of cocaine
2022;36(2):170-182.
craving after intermittent-access self-administration:
doi: 10.1177/02698811211064922 Sex differences and estrous cycle. Biol Psychiatry.
2019;85(11):915-924.
98. Di Ianni T, Ewbank SN, Levinstein MR, et al. Sex dependence
of opioid-mediated responses to subanesthetic ketamine in doi: 10.1016/j.biopsych.2019.01.015
rats. Nat Commun. 2024;15(1):893.
108. Kokane SS, Perrotti LI. Sex differences and the role of
doi: 10.1038/s41467-024-45157-7 estradiol in mesolimbic reward circuits and vulnerability
to cocaine and opiate addiction. Front Behav Neurosci.
99. Klein ME, Chandra J, Sheriff S, Malinow R. Opioid 2020;14:74.
system is necessary but not sufficient for antidepressive
actions of ketamine in rodents. Proc Natl Acad Sci U S A. doi: 10.3389/fnbeh.2020.00074
2020;117(5):2656-2662.
109. Freeman MP, Papakostas GI, Hoeppner B, et al. Sex
doi: 10.1073/pnas.1916570117 differences in response to ketamine as a rapidly acting
intervention for treatment resistant depression. J Psychiatr
100. Marton T, Barnes DE, Wallace A, Woolley JD. Concurrent Res. 2019;110:166-171.
use of buprenorphine, methadone, or naltrexone does not
inhibit ketamine’s antidepressant activity. Biol Psychiatry. doi: 10.1016/j.jpsychires.2019.01.010
2019;85(12):e75-e76.
110. Benitah K, Siegel AN, Lipsitz O, et al. Sex differences
doi: 10.1016/j.biopsych.2019.02.008 in ketamine’s therapeutic effects for mood disorders:
A systematic review. Psychiatry Res. 2022;312:114579.
101. Strong CE, Schoepfer KJ, Dossat AM, Saland SK, Wright KN,
Kabbaj M. Locomotor sensitization to intermittent ketamine doi: 10.1016/j.psychres.2022.114579
administration is associated with nucleus accumbens 111. Dakwar E, Nunes EV, Hart CL, et al. A single ketamine
plasticity in male and female rats. Neuropharmacology. infusion combined with mindfulness-based behavioral
2017;121:195-203. modification to treat cocaine dependence: A randomized
doi: 10.1016/j.neuropharm.2017.05.003 clinical trial. Am J Psychiatry. 2019;176(11):923-930.
102. Liu CL, Wang YK, Jin GZ, Shi WX, Gao M. Cocaine- doi: 10.1176/appi.ajp.2019.18101123
induced locomotor sensitization associates with slow 112. Abuse NI on D. Reduced Drug Use is a Meaningful Treatment
oscillatory firing of neurons in the ventral tegmental area. Outcome for People with Stimulant Use Disorders. National
Sci Rep. 2018;8(1):3274. Institute on Drug Abuse (NIDA); 2024. Available from:
doi: 10.1038/s41598-018-21592-7 https://nida.nih.gov/news-events/news-releases/2024/01/
reduced-drug-use-is-a-meaningful-treatment-outcome-
103. Valjent E, Bertran-Gonzalez J, Aubier B, Greengard P, for-people-with-stimulant-use-disorders [Last accessed on
Hervé D, Girault JA. Mechanisms of locomotor 2024 Jul 30].
sensitization to drugs of abuse in a two-injection protocol.
Neuropsychopharmacology. 2010;35(2):401-415. 113. Amin-Esmaeili M, Farokhnia M, Susukida R, et al.
Reduced drug use as an alternative valid outcome in
doi: 10.1038/npp.2009.143
individuals with stimulant use disorders: Findings from 13
104. Garcia-Carachure I, Flores-Ramirez FJ, Castillo SA, et al. multisite randomized clinical trials. Addict Abingdon Engl.
Enduring effects of adolescent ketamine exposure on cocaine- 2024;119(5):833-843.
and sucrose-induced reward in male and female C57BL/6 doi: 10.1111/add.16409
mice. Neuropsychopharmacology. 2020;45(9):1536-1544.
114. Roos CR, Nich C, Mun CJ, et al. Clinical validation of
doi: 10.1038/s41386-020-0654-7
reduction in cocaine frequency level as an endpoint in
105. McDougall SA, Park GI, Ramirez GI, Gomez V, Adame BC, clinical trials for cocaine use disorder. Drug Alcohol Depend.
Crawford CA. Sex-dependent changes in ketamine- 2019;205:107648.

Volume 8 Issue 1 (2025) 45 doi: 10.36922/itps.4458