Page 86 - ITPS-8-2

INNOSC Theranostics and
Pharmacological Sciences Antioxidant effects of curcumin in SCI

(P < 0.05). No meaningful difference in the BBB scores 3.2.3. GSH activity
was reported between the Model+CuC20 animals and The activity of GSH was raised in the SCI-induced animals
the Model group animals (P > 0.05). Model+CuC40 and relative to the Control group animals (P < 0.0001). Mean
Model+CuC80 animals demonstrated improvement in GSH activity was similar between the Model+CuC20
functional recovery compared to the Model group animals and the Model groups (P > 0.05). Furthermore, both the
(Figure 1, P < 0.0001 for comparisons). These results Model+CuC40 and Model+CuC80 animals demonstrated
indicate that higher doses of CuC may promote functional a substantial increase in GSH activity relative to the Model
recovery in SCI, highlighting its potential therapeutic group (Figure 4, P < 0.0001 for both treatments). These
benefits. findings suggest that the intervention may have effectively

3.2. Blood levels of OS indicators alleviated OS and contributed to improved cellular health.
3.2.1. MDA level 3.2.4. TAC level
Our findings indicated a significant rise in the level of In comparison to the Control group animals, TAC was
MDA in the Model group animals relative to the Control diminished in the SCI animals (P < 0.0001). No significant
group animals (P < 0.0001). In contrast, a notable differences in TAC levels were observed between the
reduction in MDA concentrations was observed in the
Model+CuC20 group animals relative to the Model group
animals (P = 0.01). In addition, both the Model+CuC40
and Model+CuC80 groups exhibited significant reductions
in MDA levels when compared to the Model animals
(Figure 2, P < 0.0001 for both treatments). These results
imply that CuC treatment may effectively reduce oxidative
damage in SCI, contributing to improved outcomes in
cellular health.
3.2.2. SOD activity
Our results also indicated a significant rise in SOD activity
in the Model group animals compared to the Control group
animals (P < 0.0001). No statistically significant differences
in SOD activity were reported in the Model+CuC20 group
relative to the Model group (P > 0.05). Notably, following
the administration of 40 and 80 mg/kg of CuC, there was Figure 2. CuC effects on the blood concentration of MDA in the
P<0.0001 compared to Control group; *P<0.05,
SCI-induced animals.
++++
a significant modulation in SOD levels relative to the SCI ****P<0.0001 compared to Model group.
animals (Figure 3, P < 0.0001 for both treatments). These Abbreviations: Con: Control; CuC: Curcumin; MDA: Malondialdehyde;
findings suggest that the intervention not only mitigated SCI: Spinal cord injury.
OS but also likely enhanced overall cellular health.

Figure 3. CuC effects on the blood concentration of SOD in the
SCI-induced animals. ++++ P<0.0001 compared to Control groups;
Figure 1. CuC effects on the BBB scores in experimental animals ****P<0.0001 compared to Model group.
Abbreviations: BBB score: Basso, Beattie, and Bresnahan score; Abbreviations: Con: Control; CuC: Curcumin; SCI: Spinal cord injury;
Con: Control; CuC: Curcumin. SOD: Superoxide dismutase.

Volume 8 Issue 2 (2025) 80 doi: 10.36922/itps.4795