Page 87 - ITPS-8-2

INNOSC Theranostics and
Pharmacological Sciences Antioxidant effects of curcumin in SCI

Model+CuC20 and the Model groups (P > 0.05). No statistically significant difference was observed in the
However, both the Model+CuC40 and Model+CuC NLRP3 protein levels of the Model+CuC20 group animals
80 groups demonstrated a significant elevation in TAC relative to the Model group animals (P > 0.05). However,
levels relative to the Model group (Figure 5, P < 0.0001 both the Model+CuC40 and Model+CuC80 groups
for both treatments). These results regarding TAC levels demonstrated a prominent decrease in NLRP3 protein
suggest that the intervention enhances the body’s natural levels relative to the Model group (Figure 6, P < 0.0001 for
defense mechanisms, thereby improving resilience against both treatments).
oxidative damage.
3.3.2. ASC
3.3. Protein concentrations of inflammatory Significant differences in the tissue concentration of ASC
mediators protein were observed between the Model groups and the
3.3.1. NLRP3 Control group (P < 0.0001). In contrast, no meaningful
In comparison to the control animals, the protein differences in the ASC protein level were found between the
concentrations of NLRP3 were significantly elevated in Model+CuC20 and the Model groups (P > 0.05). Following
the tissue samples of Model group animals (P < 0.0001). treatment with 40 and 80 mg/kg of CuC, there was a
significant reduction in the protein concentration of ASC
relative to the Model group animals (Figure 7, P < 0.0001
for both treatments).

Figure 4. CuC effects on the blood concentration of GSH in the
SCI-induced animals. ++++ P<0.0001 compared to Control group; Figure 6. CuC effects on the protein concentration of NLRP3 in
****P<0.0001 compared to Model group. the SCI-induced animals. ++++ P<0.0001 compared to Control group;
Abbreviations: Con: Control; CuC: Curcumin; GSH: Glutathione; ****P<0.0001 compared to Model group.
SCI: Spinal cord injury. Abbreviations: Con: Control; CuC: Curcumin; NLRP3: NOD-like
receptor family pyrin domain-containing 3; SCI: Spinal cord injury.

Figure 5. CuC effects on the blood concentration of TAC in the SCI- Figure 7. CuC effects on the protein concentration of ASC in the
induced animals. ++++ P<0.0001 compared to Control group;****P<0.0001 SCI-induced animals. ++++ P<0.0001 compared to Control group;

compared to Model group. ****P<0.0001 compared to Model group.
Abbreviations: Con: Control; CuC: Curcumin; SCI: Spinal cord injury; Abbreviations: ASC: Apoptosis-associated speck-like protein containing
TAC: Total antioxidant capacity. a CARD; Con: Control; CuC: Curcumin; SCI: Spinal cord injury.

Volume 8 Issue 2 (2025) 81 doi: 10.36922/itps.4795