Page 91 - ITPS-8-2

INNOSC Theranostics and
Pharmacological Sciences Antioxidant effects of curcumin in SCI

15. Ji ZS, Gao GB, Ma YM, et al. Highly bioactive iridium metal- signaling pathway. Basic Clin Neurosci. 2021;12(3):325-388.
complex alleviates spinal cord injury via ROS scavenging and doi: 10.32598/bcn.2021.1176.3
inflammation reduction. Biomaterials. 2022;284:121481.
25. Post M, Noreau L. Quality of life after spinal cord injury.
doi: 10.1016/j.biomaterials.2022.121481
J Neurol Phys Ther. 2005;29(3):139-146.
16. Andrabi SS, Yang J, Gao Y, Kuang Y, Labhasetwar V. doi: 10.1097/01.npt.0000282246.08288.67
Nanoparticles with antioxidant enzymes protect
injured spinal cord from neuronal cell apoptosis by 26. Mohammed I, Ijaz S, Mokhtari T, et al. Subventricular zone-
attenuating mitochondrial dysfunction. J Control Release. derived extracellular vesicles promote functional recovery
2020;317:300-311. in rat model of spinal cord injury by inhibition of NLRP3
inflammasome complex formation. Metab Brain Dis.
doi: 10.1016/j.jconrel.2019.12.001
2020;35(5):809-188.
17. Moradi F, Dashti N, Farahvash A, Naeini FB, Zarebavani M. doi: 10.1007/s11011-020-00563-w
Curcumin ameliorates chronic Toxoplasma gondii infection-
induced affective disorders through modulation of 27. Noori L, Arabzadeh S, Mohamadi Y, et al. Intrathecal
proinflammatory cytokines and oxidative stress. Iran J Basic administration of the extracellular vesicles derived from
Med Sci. 2023;26(4):461-467. human Wharton’s jelly stem cells inhibit inflammation and
attenuate the activity of inflammasome complexes after
doi: 10.22038/IJBMS.2023.68487.14937
spinal cord injury in rats. Neurosci Res. 2021;170:87-98.
18. Surguchov A, Bernal L, Surguchev AA. Phytochemicals doi: 10.1016/j.neures.2020.07.011
as regulators of genes involved in synucleinopathies.
Biomolecules. 2021;11(5):624. 28. Schwab JM, Maas AI, Hsieh JT, Curt A. Raising
awareness for spinal cord injury research. Lancet Neurol.
doi: 10.3390/biom11050624
2018;17(7):581-582.
19. Lavoie S, Chen Y, Dalton TP, et al. Curcumin, quercetin,
and tBHQ modulate glutathione levels in astrocytes and doi: 10.1016/S1474-4422(18)30206-0
neurons: Importance of the glutamate cysteine ligase 29. Mokhtari T, Yue LP, Hu L. Exogenous melatonin
modifier subunit. J Neurochem. 2009;108(6):1410-1422. alleviates neuropathic pain-induced affective disorders
by suppressing NF-κB/NLRP3 pathway and apoptosis. Sci
doi: 10.1111/j.1471-4159.2009.05908.x
Rep. 2023;13(1):2111.
20. Pan Y, Wang Y, Cai L, et al. Inhibition of high glucose‐ doi: 10.1038/s41598-023-28418-1
induced inflammatory response and macrophage infiltration
by a novel curcumin derivative prevents renal injury in 30. Jiang W, Li M, He F, Zhou S, Zhu L. Targeting the NLRP3
diabetic rats. Br J Pharmacol. 2012;166(3):1169-1182. inflammasome to attenuate spinal cord injury in mice.
J Neuroinflammation. 2017;14:207.
doi: 10.1111/j.1476-5381.2012.01854.x
doi: 10.1186/s12974-017-0980-9
21. Reyes-Fermín LM, González-Reyes S, Tarco-Álvarez NG,
Hernández-Nava M, Orozco-Ibarra M, Pedraza-Chaverri J. 31. Kim KT, Kim MJ, Cho DC, et al. The neuroprotective effect
Neuroprotective effect of α-mangostin and curcumin of treatment with curcumin in acute spinal cord injury.
against iodoacetate-induced cell death. Nutr Neurosci. Neurol Med Chir (Tokyo). 2014;54(5):387-394.
2012;15(5):34-41.
doi: 10.2176/nmc.oa.2013-0251
doi: 10.1179/1476830512Y.0000000011 32. Gao Y, Li J, Wu L, et al. Tetrahydrocurcumin provides
22. Gu G, Ren J, Zhu B, Shi Z, Feng S, Wei Z. Multiple neuroprotection in rats after traumatic brain injury:
mechanisms of curcumin targeting spinal cord injury. Autophagy and the PI3K/AKT pathways as a potential
Biomed Pharmacother. 2023;159:114224. mechanism. J Surg Res. 2016;206(1):67-76.
doi: 10.1016/j.biopha.2023.114224 doi: 10.1016/j.jss.2016.07.014
23. Panknin TM, Howe CL, Hauer M, Bucchireddigari B, 33. Dong W, Yang B, Wang L, et al. Curcumin plays
Rossi AM, Funk JL. Curcumin supplementation and human neuroprotective roles against traumatic brain injury partly
disease: A scoping review of clinical trials. Int J Mol Sci. via Nrf2 signaling. Toxicol Appl Pharmacol. 2018;346:28-36.
2023;24(5):4476.
doi: 10.1016/j.taap.2018.03.020
doi: 10.3390/ijms24054476
34. Caillaud M, Chantemargue B, Richard L, et al. Local low
24. Gholami M, Hozuri F, Abdolkarimi S, et al. Pharmacological dose curcumin treatment improves functional recovery
and molecular evidence of neuroprotective curcumin and remyelination in a rat model of sciatic nerve crush
effects against biochemical and behavioral sequels caused through inhibition of oxidative stress. Neuropharmacology.
by methamphetamine: Possible function of CREB-BDNF 2018;139:98-116.

Volume 8 Issue 2 (2025) 85 doi: 10.36922/itps.4795