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Journal of Clinical and
Basic Psychosomatics Depressive disorder obstructive sleep apnea hypothalamic inflammation

hypothalamic inflammation with BMI and AHI. The left Author contributions
hypothalamic inflammation may represent a potential
mechanism underlying the comorbidity of obesity and Conceptualization: Qiaoyang Zhang, Shumin Zhu
Formal analysis: Guanzhong Dong, Min Zhang
OSA. Anti-inflammatory therapy emerges as a potential
therapeutic approach for weight management and the Investigation: Xuanyan Zhu, Yi Ma, Y Ma, Lihao Zhang
mitigation of OSA-hypopnea. Project administration: Yin Cao
Writing – original draft: All authors
This study presents a few limitations. PSG is regarded Writing – review and editing: All authors
as the gold standard for diagnosing OSA. It can be
coupled with electroencephalography to accurately Ethics approval and consent to participate
determine actual sleep time and sleep cycles. In our All procedures involving human participants performed in
research, a portable sleep apnea monitor was used, and this study were in accordance with the ethical standards
while the three parameters we assessed demonstrated of the Institutional Ethics Committees of the Affiliated
good consistency with PSG in diagnosing moderate-to- Changzhou No. 2 People’s Hospital of Nanjing Medical
severe OSA [46,47] , the use of PSG remains the most precise University (2020KY204-01) and with the 1964 Helsinki
diagnostic tool. In addition, obese male patients were Declaration and its later amendments or comparable ethical
less likely to opt for bariatric surgery compared to obese standards. This study was registered in the Chinese Clinical
female patients. Although we collected data spanning Trial Registry (registration number: ChiCTR2100052438).
2 years, the sample size remained relatively small. Informed consent was obtained from all study participants.
Further expansion of the sample size is essential to attain
more accurate results. Consent for publication

5. Conclusion Informed consent was obtained from all study subjects.
In summary, depressive disorders are associated with the Availability of data
severity of OSA and left hypothalamic inflammation in The datasets generated during the present study are
obese young men. Notably, left hypothalamic inflammation
exhibits a positive correlation with the severity of OSA, available from the corresponding author on reasonable
request.
which suggests that left hypothalamic inflammation may
be the underlying mechanism of OSA in obese young References
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Volume 2 Issue 1 (2024) 7 https://doi.org/10.36922/jcbp.1040