Page 88 - JCBP-3-1

Journal of Clinical and
Basic Psychosomatics HDL markers and suicidal ideation

significant dose–response relationships were observed status, hypertension, diabetes, stroke, and kidney disease
between other HDL-related inflammatory indicators and (p interaction > 0.05) (Table 3).
SI (Figure 2).
4. Discussion
3.4. Associations between co-exposure to
inflammatory indicators and SI In this cross-sectional study involving 14,554 U.S. adults
conducted between 2015 and 2023, we examined the
The WQS regression identified CHR, NEU, and HDL-C as association between HDL-related inflammatory indicators
the inflammatory indicators most closely associated with and SI. Our findings revealed that elevated levels of CHR
SI. Notably, elevated CHR levels emerged as the primary were significantly associated with a higher prevalence of
contributor to the increased prevalence of SI, exerting SI. Regulating blood CHR levels could potentially serve
a more pronounced influence than elevated NEU levels as an effective strategy to reduce SI prevalence, thereby
(Figure A2).
alleviating the substantial public health burden associated
3.5. Subgroup analysis with suicide.
Subgroup analyses revealed a consistent positive Inflammatory responses, immune function, and lipid
association between CHR and SI across all subgroups, metabolism are critical mechanisms in the development
including those defined by age group, gender, race, marital of many diseases, including SI. 7,27-29 Previous studies have
status, PIR, education level, alcohol consumption, smoking highlighted the complex interactions between HDL-C and

A B C

D E F

Figure 2. Restricted cubic spline analysis of high-density lipoprotein-related inflammatory indicators and SI. (A) WHR and SI dose–response relationship;
(B) NHR and SI dose–response relationship; (C) LHR and SI dose–response relationship; (D) MHR and SI dose–response relationship; (E) CHR and SI
dose–response relationship; (F) PHR and SI dose–response relationship. The analysis was adjusted for gender, age group, race, marital status, education
level, poverty income ratio, smoking, drinking, hypertension, diabetes, stroke, and kidney disease. Reference values were defined as the median.
Abbreviations: CHR: High-sensitivity C-reactive protein-to-high-density lipoprotein cholesterol ratio; LHR: Lymphocyte-to-high-density lipoprotein
cholesterol ratio; MHR: Monocyte-to-high-density lipoprotein cholesterol ratio; NHR: Neutrophil-to-high-density lipoprotein cholesterol ratio; PHR:
Platelet-to-high-density lipoprotein cholesterol ratio; WHR: White blood cell-to-high-density lipoprotein cholesterol ratio; SI: Suicidal ideation.

Volume 3 Issue 1 (2025) 82 doi: 10.36922/jcbp.5084