Page 62 - JCBP-3-3

Journal of Clinical and
Basic Psychosomatics Depression and chronic pancreatitis: MR study

Figure 1. An overview of the design and methods used in this Mendelian randomization study
Abbreviations: CP: Chronic pancreatitis; GWAS: Genome-wide association study; ICD: International classification of diseases; IEU: Integrative
epidemiology unit; MDD: Major depression disorder; SNPs: Single-nucleotide polymorphisms.

the Reporting of Observational Studies in Epidemiology data. The total number of individuals in this dataset
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(STROBE) guidelines, specifically for MR. 20,21 is 377,277 (210,870 males and 166,407 females), with
20,175,454 variables analyzed. The dataset includes
2.1.1. Genetic instruments and data sources for 3320 cases of CP (https://risteys.finregistry.fi/endpoints/
depression K11_CHRONPANC). CP endpoints are defined using the

The GWAS summary statistics for depression were International Classification Of Diseases (ICD)-8, ICD-9,
obtained from the Psychiatric Genomics Consortium (the and ICD-10 codes, along with registry filters (Table S1).
largest biological investigation in the history of psychiatry)
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and the UK Biobank. This includes meta-analyses of 2.1.3. Genetic instruments and data sources for
33 cohorts from the Psychiatric Genomics Consortium multivariable exposures and potential mediators
(excluding 23andMe and the UK Biobank data), focusing We selected smoking, alcohol consumption, type 2
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on clinically derived phenotypes for major depression diabetes, body mass index (BMI), and triglycerides as
disorder (MDD) and the broad depression phenotype multivariable confounding factors to explore the direct
in the full release of the UK Biobank. The total sample effect of depression on CP. These IVs were selected from the
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size is 500,199 (170,756 cases and 329,443 controls), with most recent and largest authoritative studies, as shown in
8,483,301 variables analyzed. Basic information about the Figure 1. In addition, we reviewed clinical manifestations
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database and specific definitions of depression phenotypes and relevant MR literature to explore potential mediating
is shown in Table S1. factors. In previous MR studies, depression has been
associated with multiple factors, while CP has been
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2.1.2. Genetic instruments and data sources for CP linked to lifestyle, disease factors, biochemical indices,
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The GWAS summary statistics for CP were sourced lipid and glucose metabolism, and obesity characteristics.
from the latest R9 version of the FinnGen Consortium Based on these associations, we identified common factors

Volume 3 Issue 3 (2025) 56 doi: 10.36922/jcbp.5892