Page 57 - JCBP-3-3

Journal of Clinical and
Basic Psychosomatics Integrative neurodegenerative care

significantly reduce financial barriers to early diagnosis and Beyond cost, data management and interpretation
routine monitoring, particularly in primary care settings and pose additional challenges. Although the quantitative
underserved populations. Compared to costly monoclonal nature of these assessments allows for structured analysis,
antibody treatments like aducanumab, which only achieved maintaining accurate and up-to-date patient records
cost-effectiveness at an annual price of $22,820, our is critical for reliable longitudinal tracking. Without
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integrated diagnostic framework offers a sustainable, lower- centralized databases or standardized reference values,
cost solution for longitudinal ADR monitoring. clinical adoption may vary between healthcare settings.
Scalability remains another major strength of this Developing cloud-based platforms and AI-assisted
approach. Unlike large-scale neuroimaging infrastructure, data processing tools could enhance usability, enabling
which requires specialized facilities, trained personnel, automated risk classification and real-time clinical decision
and high-cost maintenance, eye-tracking and reaction- support.
retention testing can be conducted in outpatient settings Regulatory considerations must also be addressed
or remotely through telemedicine platforms. Future before these technologies can be integrated into routine
advancements in wearable and mobile health technology clinical practice. Although these tools are non-invasive,
may further enhance the reach of this framework, enabling they require rigorous validation against established ADR
real-time cognitive monitoring beyond traditional clinical diagnostics and alignment with clinical guidelines to
environments. These innovations could be especially ensure diagnostic accuracy and consistency. Large-scale
valuable for longitudinal tracking in high-risk individuals, clinical trials and multicenter validation studies will be
supporting earlier detection and proactive intervention essential to confirm their sensitivity and specificity relative
for ADR-related cognitive decline while reducing overall to traditional methods, such as PET imaging and CSF
healthcare costs. biomarkers.
While this integrative diagnostic framework offers a Moving forward, expanding validation studies will be
cost-effective and scalable approach to ADR screening, it is critical for establishing diagnostic thresholds and refining
not intended to replace existing gold-standard diagnostics clinical applications of saccadic velocity, reaction time,
such as PET imaging or CSF analysis. Rather, this approach and stress-related biomarkers. Integrating wearable and
serves as a complementary tool, potentially enhancing early telemedicine-based monitoring solutions could further
detection and routine monitoring, particularly in primary enhance accessibility, reducing reliance on frequent
care and telemedicine settings where access to traditional in-clinic visits while enabling continuous tracking of ADR
methods may be limited. Further validation through progression. In addition, incorporating AI-driven analytics
clinical research is necessary to establish its comparative into clinical workflows has the potential to streamline
effectiveness and long-term utility in practice. data interpretation, reduce clinician burden, and improve
diagnostic efficiency.
6. Challenges and future directions
By addressing these challenges through technological
While the integration of eye-tracking, reaction-retention advancements, interdisciplinary collaboration, and large-
testing, and the SRSS offers a promising non-invasive scale validation efforts, this framework could enhance
diagnostic approach, several barriers to widespread early ADR detection, improve patient outcomes, and
clinical adoption remain. One of the most significant increase accessibility to cognitive health monitoring in
challenges is patient adherence, particularly in individuals both primary care and specialized memory clinics.
with cognitive impairment, where engagement with
technology-based assessments may fluctuate over time. 7. Conclusion
Ensuring consistent data collection requires streamlined The integration of eye-tracking, reaction-retention
protocols, caregiver involvement, and user-friendly testing, and the SRSS represents a novel paradigm in ADR
interfaces that accommodate varying levels of digital diagnostics, offering a holistic, non-invasive, and scalable
literacy and cognitive function. approach for early detection and disease monitoring. By
Another key challenge is the cost and scalability of eye- bridging physiological and psychological assessments,
tracking technology for clinical applications. While lower- this framework provides a comprehensive profile of
cost models exist, access to high-quality, validated devices cognitive and emotional health, supporting personalized
remains limited, particularly in resource-constrained disease management strategies. However, further research
settings. Exploring alternative approaches, such as virtual is required to validate these methods against gold-
reality-based eye-tracking systems, could improve cost- standard diagnostic tools, establish clinical diagnostic
effectiveness while maintaining diagnostic reliability. thresholds, and refine protocols for large-scale deployment.

Volume 3 Issue 3 (2025) 51 doi: 10.36922/jcbp.8349