Page 55 - JCBP-3-3

Journal of Clinical and
Basic Psychosomatics Integrative neurodegenerative care

Figure 2. Clinical workflow for neurodegenerative disease monitoring. (A) Questionnaire: The assessment begins with the 8-item short recovery-stress
scale to evaluate the subject’s current cognitive, emotional state, and subjective physical well-being highlighting aspects such as physical and mental
capability, emotional balance, overall recovery, muscle soreness, lack of activation, negative emotional state, and overall stress. (B) Eye-tracking glasses:
Eye-tracking glasses are used to monitor retina movements, gathering data on visual attention, processing speeds, and metrics such as fixation duration,
saccade amplitude, and pupil responses, which are critical in assessing cognitive functions. (C) Light activation: Colored lights (red, yellow, green) turn on
in a randomized order. This step is designed to test the subject’s reaction times and attention to visual stimuli. (D) Reaction response button: The subject
presses a button to acknowledge each colored light, which measures response accuracy and speed, further contributing to the evaluation of sensory and
cognitive response capabilities. (E) Retention test: The subject is tasked with recalling either the color or number sequence shown on a screen, testing
memory retention and cognitive response. This helps in assessing higher cognitive functions and memory integration.

its use in elderly populations with ADR. Potential Table 1. Integrated diagnostic framework for ADR
19
refinements could include adjustments in questionnaire monitoring
structure or scoring systems to better capture age-related Assessment Metrics evaluated Risk
variations in stress perception and recovery patterns. component model (%)

4.4. Synthesizing diagnostic data for clinical Eye-tracking Saccadic velocity, fixation 50
stability, pupillometry
interpretation
Reaction-retention Processing speed, memory 30
To ensure clinically actionable insights, data from eye- testing recall accuracy
tracking, reaction-retention testing, and SRSS assessments Short recovery-stress Recovery-stress balance, 20
must be systematically integrated into a unified risk scale fatigue indicators
assessment model. The proposed diagnostic workflow Abbreviation: ADR: Alzheimer’s and dementia-related diseases.
consists of three key components:
(i) Baseline data collection over 30 days to establish Table 2. Risk classification and clinical recommendations
individualized normative values
(ii) Automated flagging of significant deviations beyond Risk class Deviation (%) Clinical action
established thresholds Low 0 – 30 Stable cognitive function; annual
(iii) Multi-metric analysis and risk classification using a monitoring recommended
weighted scoring model (Table 1). Moderate 31 – 60 Early ADR indicators detected;
follow-up neuroimaging
The risk classification model translates deviations from (PET imaging/CSF biomarkers) advised
baseline data into clinical recommendations, helping High >60 Severe cognitive impairment;
clinicians distinguish ADR-related cognitive impairment immediate referral for ADR diagnostic
from external influences such as stress or sleep disturbances confirmation.
(Table 2). Abbreviations: ADR: Alzheimer’s and dementia-related diseases;
CSF: Cerebrospinal fluid; PET: Positron emission tomography.
By leveraging a weighted multi-metric model,
this approach accounts for both physiological and changes in cognitive function by comparing new data
psychological contributors to ADR progression, enhancing against established baselines. For example, a patient
diagnostic precision. Clinicians can track longitudinal initially classified as moderate risk (31 – 60% deviation)

Volume 3 Issue 3 (2025) 49 doi: 10.36922/jcbp.8349