Page 24 - JCTR-11-3

Journal of Clinical and
Translational Research Immunogenicity and safety of flu vaccines

References 26 20 19 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 (Cont’d...)

Type of virus strain IIV3 H1N1 IIV4 IIV4 IIV3 IIV4 IIV3 H1N1 IIV4 IIV3 IIV4 IIV3 IIV4/ IIV3 IIV4/ IIV3 H1N1/ IIV3 IIV3 IIV3 IIV4/ IIV3 IIV4/ IIV3 IIV3

HA per strain (μg/dose) 15 3.75, 7.5, 15 15 15 15 15 7.5 3.75, 7.5, 15 15 7.5, 15 15 15 15 7.5, 15 15 15 15 15 15 15

Adjuvant Non-adjuvanted/

MF59 MF59 MF59 MF59 MF59 None MF59 MF59 None MF59 None None None MF59 None MF59 MF59 MF59 None None

Duration 2011 – 2012 2009 – 2011 2014 – 2016 2016 – 2017 2010 – 2014 2013 – 2014 2014 – 2015 2009 – 2011 2018 – 2019 2012 – 2013 2020 – 2021 2013 – 2014 2013 – 2014 2013 – 2015 2008 – 2010 2010 – 2011 2017 – 2018 2017 – 2019 2014 – 2015 2013 – 2014

≥65 years 22 years ≥65 years ≥65 years 6 – 72 months 6 – 35 months ≥18 years 6 – 71 months ≥3 years ≥18 years ≥18 years 5 years ≥65 years 6 years 18 years 18 years
Age 3 – 17 years 6 months – 4 – 18 years 6 months – 18 – 65 years 65 – 82 years 6 months – 6 months – 6 months –

Number of participants 911 666 2,208 6,790 770 2,333 287 330 480 296 3,000 1,503 2,680 10,644 15,044 7,082 3,283 424 454 384

Vaccine produced in Egg Egg Egg Egg Egg Cell Egg Egg Cell Egg Egg Cell Cell Cell Egg Egg Egg Egg Cell Cell

Country Canada Germany, Belgium, Netherlands, Dominican Republic, Chile Finland, USA, Philippines, Thailand Bulgaria, Colombia, Czech Republic, Estonia, Latvia, Lithuania, Malaysia, Philippines, Poland, Romania, Thailand, Turkey Korea USA Mexico Germany, Belgium, Netherlands, Dominican Republic, Chile India Senegal China Korea USA Finland, USA, Canada, Italy, Poland, Spain, Philippines, Thailand, Taiwan (China) Australia, New Zealan

Table 1. Description of included studies Study Year design Prospective 2013 Prospective 2015 Prospective 2020 Prospective 2021 Prospective 2018 Prospective 2015 Hartvickson et al. Prospective 2018 Cruz-Valdez et al. Prospective 2014 Prospective 2021 Prospective 2018 Prospective 2022 Prospective 2017 Prospective 2016 Prospective 2018 Prospective 2016 Prospective 2014 Prospective 2020 Prospective 2021 Prospective 2019

Scheifele et al.
Cowling et al.
First author
Loeb et al.
Basu et al.
Knuf et al.
Frey et al.
Eun et al.
Oh et al.
Volume 11 Issue 3 (2025) Vesikari et al. Beran et al. Yoo et al. Knuf et al. 18 Diallo et al. Zhang et al. Choi et al. Bart et al. Vesikari et al. Mcbride et al. doi: 10.36922/JCTR025060006