Page 77 - JCTR-11-3

Journal of Clinical and

Translational Research

ORIGINAL ARTICLE
Maternal and neonatal outcomes in placenta

previa complicated by anterpartum hemorrhage

Inshal Jawed* , Mohammad Omer Alam, Hina Khan, Vikash Kumar Karmani,
Muhammad Umair, Farah Abdul Razzak, Abu Huraira Bin Gulzar, Anish Kumar,
Mehak Raheel Khan, and Farah Alam
Department of Surgery, Qatar Hospital Karachi, Karachi, Pakistan

Abstract
Background: Antepartum hemorrhage (APH) during pregnancy has a significant
impact on both mothers and neonates. Aim: This study aims to investigate
maternal and neonatal outcomes by retrospectively analyzing placenta previa
(PP) cases complicated by APH. Methods: This study retrospectively investigated
50 cases of singleton pregnancies in women diagnosed with PP managed at a
tertiary care Hospital in Karachi, Pakistan, from January to October 2024. The
participants recruited were of a gestation period ranging from 24 to 42 weeks.
The participants were categorized into two groups: APH and non-APH. The study
assessed various maternal clinical characteristics. Ultrasound exams were conducted
*Corresponding author: using standardized methods. Perinatal outcomes for mothers and newborns were
Inshal Jawed
(Inshaljwd@gmail.com) compared, including complications such as preterm delivery, placental abruption,
and neonatal issues. Mann–Whitney U test, Student’s t-test, Chi-square test, and
Citation: Jawed I, Alam MO,
Khan H, et al. Maternal and binary logistic regression were employed for statistical analysis. Results: Women
neonatal outcomes in placenta afflicted with APH exhibited significantly higher maternal age compared to those
previa complicated by anterpartum without APH (p=0.029). Furthermore, we discovered a notable statistical difference
hemorrhage. J Clin Transl Res.
2025;11(3):71-79. in the type of PP between the two groups. Specifically, complete PP was observed
doi: 10.36922/jctr.25.00002 in 27.3% of women with APH but only in 4.3% of those without APH. The gestational
Received: January 15, 2025 age at delivery for pregnant women with APH was notably shorter compared to
those without APH, leading to a considerably higher incidence of both lower birth
1st revised: March 11, 2025
weights and preterm deliveries when APH was present, in contrast to cases where
2nd revised: April 3, 2025 APH was absent. Conclusion: APH has a significant association with maternal and
Accepted: April 16, 2025 neonatal outcomes, especially in cases of PP. Thus, timely interventions are necessary
to prevent APH to mitigate further complications in mothers and newborns.
Published online: May 7, 2025
Relevance for Patients: The research demonstrates why prompt diagnosis and
Copyright: © 2025 Author(s). on-time care interventions improve maternal–fetal health outcomes during APH
This is an Open-Access article
distributed under the terms of the incidents, specifically in PP patients.
Creative Commons AttributionNon-
Commercial 4.0 International (CC
BY-NC 4.0), which permits all Keywords: Antepartum hemorrhage; Pregnancy; Placenta previa; Perinatal outcomes
non-commercial use, distribution,
and reproduction in any medium,
provided the original work is
properly cited.
Publisher’s Note: AccScience 1. Introduction
Publishing remains neutral with The term “placenta previa” (PP) is defined as the partial or complete obstruction of the
regard to jurisdictional claims in
published maps and institutional internal os of the cervix that occurs during pregnancy when the placenta is situated low
affiliations. in the uterus. The overall incidence of this disorder ranges between 0.3% and 2% during

Volume 11 Issue 3 (2025) 71 doi: 10.36922/jctr.25.00002