Page 83 - JCTR-11-3

Journal of Clinical and
Translational Research Outcomes of placenta previa with APH

access and socioeconomic factors. The prevalence was analysis of predisposing factors and genetics should be
the lowest in Africa despite the resource-limited settings conducted with the purpose of improving the current
and low socioeconomic status. The lower incidence can be detection methods in terms of their efficacy, to mitigate
attributed to the underreporting of the cases, small sample the burden of mortality and morbidity in APH cases. In
sizes, and low number of studies conducted. Moreover, it addition, perennial challenges such as resource constraints
also been found that there is a negative correlation between and lack of financial support, as well as the low rate of
the incidence of APH due to PP and years of reporting medical consultations and patients’ follow-up, facing the
(correlation coefficient [r] = −0.01, 95% CI: −0.02 – 0.001, developing countries are elevated to not only a clinical
p=0.03). Furthermore, multiparous pregnancies had a but also a socioeconomic issue. Furthermore, larger-scale
significantly positive correlation with the incidence of epidemiological studies are needed in regions like Asia
APH due to PP (correlation coefficient [r] = 0.66, 95% or Africa in order to have a clear understanding of the
CI: 0.08 to 1.24, p=0.03). Thus, these correlation results incidence and burden of APH among patients with PP.
support the conjecture that previous pregnancy history These recommended actions should be executed to aid in
plays a role in APH incidence and contributes to future the introduction of strategies focused on maternal and fetal
outcomes. According to epidemiological data, the health intended to lower the burden of this multifactorial
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average prevalence has shown gradual reduction over time. complication and both the maternal and fetal mortalities
Although the leading causes responsible for the decreased and morbidities in developing regions.
APH occurrence were not analyzed, it is very likely
that improvements in the national healthcare systems, 5. Conclusion
diagnostic procedures, and obstetric practice collectively The current study demonstrates the significant impact
contribute to the case reduction. Robust healthcare systems of APH during pregnancy on maternal and neonatal
help deliver safe, timely, and appropriate cesarean sections, outcomes. The results emphasize the need for vigilant
ensuring optimal health results for women and newborns monitoring and timely interventions in pregnant women
during emergency obstetrics. A multidisciplinary with PP to address modifiable risk factors via antenatal
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approach taking into account maternal and fetal outcomes, care, patient education, and preventive strategies so as
strict monitoring, timely interventions, and patient to mitigate the risk of APH and its associated adverse
education is required to effectively manage APH in patients consequences for both mothers and newborns.
with PP. Early detection of PP can be helpful in timely
diagnosis and effective management of patients. This can Acknowledgments
be achieved by second-trimester ultrasounds to identify
the placental location, followed by serial scans to monitor We would like to extend our gratitude to Qatar Hospital
the condition with time. However, once a diagnosis is Karachi for providing the required resources, infrastructure,
confirmed, the patient should be counseled about her and proper clinical settings to ensure the successful
condition and must be educated accordingly regarding execution of our observational study. Furthermore, we
the potential complications and the need for medical care would like to thank the hospital’s healthcare professionals,
if bleeding occurs. Planning a delivery effectively is the staff, and administration, who made the study possible by
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cornerstone of managing such complicated cases; as for helping us with data collection and patient management.
stable patients who do not have significant bleeding, an Funding
elective cesarean section can be scheduled between 36 and
37 weeks for optimal neonatal outcomes and avoidance of None.
spontaneous labor. Severe bleeding cases can be managed
by a prompt delivery subsequent to a cesarean section and Conflict of interest
a corticosteroid administration for ensuring fetal lung The authors declare that they have no competing interests
maturity. 23 to declare.
The advice incorporates early diagnosis followed by
proper monitoring combined with planned C-section Author contributions
delivery to minimize the chances of complex gestational Conceptualization: Inshal Jawed
complications among pregnant women affected by PP. Data curation: Mohammad Omer Alam, Hina Khan,
However, future research shall focus on unraveling the Vikash Kumar Karmani
underlying mechanisms behind abnormal placental Formal analysis: Mohammad Omer Alam
implantation and finding innovative management Investigation: Muhammad Umair, Abu Huraira bin Gulzar,
techniques for effective management. An in-depth Farah Abdul Razzaq, Anish Kumar

Volume 11 Issue 3 (2025) 77 doi: 10.36922/jctr.25.00002