Page 76 - JCTR-11-4

Journal of Clinical and
Translational Research Adherence and psoriasis severity in Brazil

adherence. Selecting a therapeutic option that is convenient, Funding
effective, cost-effecient, and well-tolerated—along with
pharmacotherapeutic monitoring—can significantly This work is supported by Conselho Nacional de
enhance adherence and optimize psoriasis management. Desenvolvimento Científico e Tecnológico (Grant no.:
These measures can improve the patient’s quality of life and 313349/2021-5, 315628/2021-9); INCT-INOVAMED
(Grant no.: 465430/2014-7); and Coordenação de
reduce costs for both the patient and the healthcare system. 29
Aperfeiçoamento de Pessoal de Nível Superior for
This study has several limitations. Firstly, its cross- scholarships to Kauê Cézar Sá Justo and Fernando
sectional design prevents the establishment of causal Henrique Teixeira Zonzini.
relationships between the severity of psoriasis and the
associated sociodemographic and clinical factors. Data Conflict of interest
collected were restricted to selected dermatology centers, The authors declare that they have no conflicts of interest.
which may limit the generalizability of the findings,
particularly for patients who do not seek specialized Author contributions
care. In addition, variables such as treatment adherence
and lifestyle habits were self-reported, which could Conceptualization: Kauê Cézar Sá Justo, Fernando
introduce recall bias or inaccuracies. The sample size Henrique Teixeira Zonzini, Aguinaldo Bonalumi
of 133 participants, while sufficient for this analysis, Filho, João Batista Calixto, Daniela Almeida Cabrini,
Michel Fleith Otuki
limited the statistical power, preventing the execution Investigation: Kauê Cézar Sá Justo, Fernando Henrique
of the originally planned nonparametric tests. Finally,
although the study collected extensive data on clinical, Teixeira Zonzini, Aguinaldo Bonalumi Filho, Anber
sociodemographic, and treatment-related factors, it did Ancel Tanaka, Jessica Scherer Dagostini, Rogerio
Nabor Kondo, Adriane Reichert Faria
not thoroughly assess psychological aspects, which are Methodology: Kauê Cézar Sá Justo, Fernando Henrique
known to influence both psoriasis severity and quality Teixeira Zonzini, Aguinaldo Bonalumi Filho
of life. Future research should address these gaps by
employing longitudinal designs, increasing sample size, Writing – original draft: Kauê Cézar Sá Justo, Fernando
and incorporating detailed psychological assessments. Henrique Teixeira Zonzini, Daniela Almeida Cabrini,
Michel Fleith Otuki
5. Conclusion Writing – review & editing: Kauê Cézar Sá Justo, Fernando
Henrique Teixeira Zonzini, Aguinaldo Bonalumi
Our study shows a connection between treatment Filho, João Batista Calixto, Daniela Almeida Cabrini,
adherence and psoriasis severity, emphasizing that Michel Fleith Otuki
choosing the right therapy alone is not enough to achieve
the best results. Treatment interruptions were associated Ethics approval and consent to participate
with increased psoriasis severity. In contrast, patients with This study was approved by the Human Research Ethics
higher treatment adherence had lower psoriasis severity. Committee of the Health Sciences Sector, Federal
These findings highlight the critical role of consistent University of Paraná (SCS/UFPR) under approval number
adherence in effective disease management. To improve 4.294.864, issued in 2021. All participants consented to be
patient outcomes, healthcare providers should prioritize part of the study via the ICF.
regular follow-ups and patient education—simple yet
powerful tools that can enhance treatment success, improve Consent for publication
quality of life, and reduce healthcare costs. Our findings
suggest that supporting better treatment adherence should Patients consented on the publication of their data.
be a key priority in psoriasis management strategies.
Availability of data
Acknowledgments Data is available from the corresponding author upon
The authors thank the Coordination for the Improvement reasonable request.
of Higher Education Personnel (CAPES), National Council References
for Scientific and Technological Development (CNPQ),
National Institute of Science and Technology-Innovation 1. Michalek IM, Loring B, John SM. A systematic review of
in Medicines and Identification of New Therapeutic worldwide epidemiology of psoriasis. J Eur Acad Dermatol
Targets (INCT/INOVAMED), and the Federal University Venereol. 2017;31(2):205-212.
of Paraná (UFPR). doi: 10.1111/jdv.13854

Volume 11 Issue 4 (2025) 70 doi: 10.36922/jctr.24.00057