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Microbes & Immunity                                                     Copper and cuproptosis in immunity



            thorough  studies  of  cuproptosis  and  its  associated  genes   on mechanical properties of biocompatible Ti-mo alloys:
            necessitate well-designed pre-clinical experiments and   A  simulation-based investigation.  Micromachines (Basel).
            clinical  trials,  which  present  significant  implementation   2023;14(5):1081.
            challenges. Nonetheless, this is a promising research area,      doi: 10.3390/mi14051081
            and we look forward to future advancements.
                                                               4.   Huang X, Li Q, Yun S, et al. Zn(II) enhances the antimicrobial
            Acknowledgments                                       effect of chloroxine and structural analogues against drug-
                                                                  resistant ESKAPE pathogens in vitro. Biochem Pharmacol.
            None.                                                 2024;229:116482.

            Funding                                               doi: 10.1016/j.bcp.2024.116482
                                                               5.   Hager S, Korbula K, Bielec B, et al. The thiosemicarbazone
            This work was supported by the Chongqing Postdoctoral   Me NNMe  induces paraptosis by disrupting the ER thiol
            Science Foundation (7820100597) and the Natural Science   redox homeostasis based on protein disulfide isomerase
                                                                          2
                                                                     2
            Foundation (grant numbers: 82072246, 82211530059).    inhibition. Cell Death Dis. 2018;9(11):1052.
            Conflict of interest                                  doi: 10.1038/s41419-018-1102-z
            Jianping Xie is the Editorial Board Member of this journal   6.   Wang M, Huang H, Ma X, Huang C, Peng X. Copper metal-
            but was not in any way involved in the editorial and   organic framework embedded carboxymethyl chitosan-g-
                                                                  glutathione/polyacrylamide hydrogels for killing bacteria
            peer-review process conducted for this paper, directly or   and  promoting wound  healing.  Int J Biol Macromol.
            indirectly. Separately, other authors declared that they   2021;187:699-709.
            have no known competing financial interests or personal
            relationships that could have influenced the work reported      doi: 10.1016/j.ijbiomac.2021.07.139
            in this paper.                                     7.   Culbertson EM, Culotta VC. Copper in infectious disease:
                                                                  Using both sides of the penny.  Semin Cell Dev Biol.
            Author contributions                                  2021;115:19-26.
            Conceptualization: All authors                        doi: 10.1016/j.semcdb.2020.12.003
            Visualization: Junqi Xu                            8.   Gao L, Zhang A. Copper-instigated modulatory cell
            Writing–original draft: All authors                   mortality mechanisms and progress in oncological treatment
            Writing–review & editing: All authors                 investigations. Front Immunol. 2023;14:1236063.

            Ethics approval and consent to participate            doi: 10.3389/fimmu.2023.1236063
            Not applicable.                                    9.   Zuhra K, Panagaki T, Randi EB,  et al. Mechanism of
                                                                  cystathionine-beta-synthase inhibition by disulfiram:
            Consent for publication                               The role of bis(N,N-diethyldithiocarbamate)-copper(II).
                                                                  Biochem Pharmacol. 2020;182:114267.
            Not applicable.
                                                                  doi: 10.1016/j.bcp.2020.114267
            Availability of data                               10.  May KL, Lehman KM, Mitchell AM, Grabowicz M. A stress
                                                                  response monitoring lipoprotein trafficking to the outer
            Not applicable.                                       membrane. mBio. 2019;10(3):e00618-19.

            References                                            doi: 10.1128/mBio.00618-19
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            Volume 2 Issue 1 (2025)                         66                               doi: 10.36922/mi.5657
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