Page 98 - MI-2-1
P. 98
Microbes & Immunity Hyphaene thebaica honey as a multitarget therapeutic product
human peripheral blood lymphocytes against irinotecan- 81. Hussein SZ, Mohd YK, Makpol S, Mohd YA. Gelam honey
induced cytogenetic damage in vitro. Chem Biol Interact. attenuates carrageenan-induced rat paw inflammation via
2021;349:109672. NF-kappaB pathway. PLOS One. 2013;8:e72365.
doi: 10.1016/j.cbi.2021.109672 doi: 10.1371/journal.pone.0072365
71. Thomas HR, Hu B, Boyraz B, et al. Metaplastic breast cancer: 82. Moskwa J, Borawska MH, Markiewicz-Zukowska R, et al.
A review. Crit Rev Oncol Hematol. 2023;182:103924. Polish natural bee honeys are anti-proliferative and anti-
metastatic agents in human glioblastoma multiforme
doi: 10.1016/j.critrevonc.2023.103924
U87MG cell line. PLOS One. 2014;9:e90533.
72. López EP, García FG, Jornet PL. Combination of doi: 10.1371/journal.pone.0090533
5-Florouracil and polyphenol EGCG exerts suppressive
effects on oral cancer cells exposed to radiation. Arch Oral 83. Majtan J, Bohova J, Garcia-Villalba R, et al. Fir honeydew
Biol. 2019;101:8-12. honey flavonoids inhibit TNF- α-induced MMP-9
expression in human keratinocytes: A new action of honey
doi: 10.1016/j.archoralbio.2019.02.018
in wound healing. Arch Dermatol Res. 2013;305(7):619-627.
73. Chung SS, Dutta P, Austin D, Wang P, Awad A, Vadgama JV. doi: 10.1007/s00403-013-1385-y
Combination of resveratrol and 5-flurouracil enhanced anti-
telomerase activity and apoptosis by inhibiting STAT3 and 84. Vijayababu MR, Arunkumar A, Kanagaraj P,
Akt signaling pathways in human colorectal cancer cells. Venkataraman P, Krishnamoorthy G, Arunakaran J.
Oncotarget. 2018;9:32943. Quercetin downregulates matrix metalloproteinases 2 and 9
proteins expression in prostate cancer cells (PC-3). Mol Cell
doi: 10.18632/oncotarget.25993 Biochem. 2006;287:109-116.
74. Riahi-Chebbi I, Souid S, Othman H, et al. The phenolic doi: 10.1007/s11010-005-9085-3
compound kaempferol overcomes 5-fluorouracil
resistance in human resistant LS174 colon cancer cells. Sci 85. Jaganathan SK, Mandal M. Honey Constituents and their
Rep. 2019;9:195. apoptotic effect in colon cancer cells. J Apiprod Apimed Sci.
2009;1:29-36.
doi: 10.1038/s41598-018-36808-z
doi: 10.3896/IBRA.4.01.2.02
75. Martin TA, Ye L, Sanders AJ, Lane J, Jiang WG. Cancer
Invasion and metastasis: Molecular and cellular perspective. 86. Aazza S, Lyoussi B, Antunes D, Miguel MG. Physicochemical
In: Madam Curie Biosciences Database. Austin, TX, USA: characterization and antioxidant activity of 17 commercial
Landes Bioscience; 2000. Moroccan honeys. Int J Food Sci Nutr. 2014;65(4):449-457.
76. Price JT, Thompson EW. Mechanisms of tumour invasion doi: 10.3109/0 9637486.2013.873888
and metastasis: Emerging targets for therapy. Expert Opin 87. Khalil MI, Moniruzzaman M, Boukraâ L, et al.
Ther Targets. 2002;6:217-233. Physicochemical and antioxidant properties of Algerian
doi: 10.1517/14728222.6.2.217 honey. Molecules. 2012;17(9):11199-11215.
77. Oršoli´c N, Baši´c I. Antimetastatic effect of honey. Mellifera. doi: 10.3390/molecules170911199
2004;4:38-43. 88. Bertoncelj J, Doberšek U, Jamnik M, Golob T. Evaluation
78. Reddy RA, Kumar RS. Matrix metalloproteinase-2 (MMP- of the phenolic content, antioxidant activity and colour of
2): As an essential factor in cancer progression. Recent Pat Slovenian honey. Food Chem. 2007;105(2):822-828.
Anticancer Drug Discov. 2023; 20:26-44. doi: 10.1016/j.foodchem.2007.01.060
doi: 10.2174/0115748928251754230922095544 89. Rathod NB, Elabed N, Punia S, Ozogul F, Kim SK, Rocha JM.
79. Ho HH, Chang CS, Ho WC, Liao SY, Wu CH, Wang CJ. Recent developments in polyphenol applications on human
Anti-metastasis effects of gallic acid on gastric cancer cells health: A review with current knowledge. Plants (Basel).
involves inhibition of NF-κB activity and downregulation 2023;12(6):1217.
of PI3K/AKT/small GTPase signals. Food Chem Toxicol. doi: 10.3390/plants12061217
2010;48:2508-2516.
90. Dong R, Zheng Y, Xu B. Phenolic profiles and antioxidant
doi: 10.1016/j.fct.2010.06.024 capacities of Chinese unifloral honeys from different botanical
and geographical sources. Food Bioproc Tech. 2013;6:762-770.
80. Batumalaie K, Zaman SS, Mohd YK, Shah II, Devi SS,
Qvist R. Effect of gelam honey on the oxidative stress- doi: 10.1007/s11947-011-0726-0
induced signaling pathways in pancreatic hamster cells. Int J 91. Beretta G, Granata P, Ferrero M, Orioli M, Facino RM.
Endocrinol. 2013;2013:367312.
Standardization of antioxidant properties of honey by a
doi: 10.1155/2013/367312 combination of spectrophotometric/fluorimetric assays and
Volume 2 Issue 1 (2025) 90 doi: 10.36922/mi.4994

