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Microbes & Immunity Hyphaene thebaica honey as a multitarget therapeutic product

anti-inflammatory, antiplatelet, antiulcer, and anticancer Funding
effects. It has been shown to inhibit growth and induce
apoptosis in certain colon cancer cells and to prevent This work was financially supported by the Al-Qasemi
cancer in a short-term animal model. In addition, this Research Foundation and the Arab American University-
95
Palestine (AAUP) Research Foundation.
study examined the antibacterial activity of p-coumaric
acid, suggesting its potential use in treating microbiome- Conflict of interest
95
related inflammation or cancer. P-coumaric acid was
found in relatively high quantities in the honey samples Bashar Saad is the Editorial Board Member of this journal
(Table 4). and the Guest Editor of this special issue but was not in
any way involved in the editorial and peer-review process
Carvacrol, a compound present in plants such as conducted for this paper, directly or indirectly. Separately,
oregano and thyme, has demonstrated medicinal potential, other authors declared that they have no known competing
particularly against various types of cancer cells. Copper financial interests or personal relationships that could have
complexes, along with other organometallic compounds, influenced the work reported in this paper.
are also recognized as potent anticancer agents, effective
against a variety of cancer types, including lung and Author contributions
leukemia cells. Copper, being an endogenous metal, is Conceptualization: Badiaa Lyousi, Bashar Saad
non-toxic to normal cells, contributing to its therapeutic Formal analysis: Basheer Abu-Farich, Bashar Saad
value. 96 Investigation: Hadeel Hamarshi, Doha Weldali, Abderrazak
Pinocembrin has been shown to inhibit the viability, Aboulghazi, Mohammed El Ouassete
migration, and invasiveness of colorectal cancer cells Methodology: Basheer Abu-Farich, Mahmud Masalha
while reducing the expression of MMP-2 and N-cadherin, Writing–original draft: Bashar Saad
and promoting the expression of E-cadherin and beta- Writing–review & editing: All Authors
lactamase-like protein. 97,98
In a study by Ho et al., the levels of gallic acid, a Ethics approval and consent to participate
79
compound with known antioxidant, anti-inflammatory, Not applicable.
antimutagenic, anticancer, and cardioprotective properties, Consent for publication
were found to vary in two types of Malaysian honey.
Gallic acid, characterized by its trihydroxylated phenolic Not applicable.
structure, has been identified in several honey samples. 47,66
Availability of data
4. Conclusion Data are available upon reasonable request to the
This study aimed to evaluate the biological effects of corresponding author.
DH, focusing on its antibacterial activity as well as its
antioxidant, anti-inflammatory, cytotoxic, cytostatic, References
and antimigration effects on MDA human breast cancer 1. Saad B. Exploring natural products: Novel insights and
cells. A quantitative HPLC analysis identified nine therapeutic potential of plant-based compounds. Microbes
phenolic compounds across three honey samples. The Immunity. 2024;1:1-2.
results obtained affirm the antibacterial attributes of doi: 10.36922/mi.4453
DH and attribute its potential anticancer advantages 2. Tang KW, Millar BC, Moore JE. Antimicrobial resistance
to its anti-inflammatory, antioxidant, cytostatic, and (AMR). Br J Biomed Sci. 2023;80:11387.
antimigration effects. These effects are strongly linked
to the presence of specific polyphenols, including doi: 10.3389/bjbs.2023.11387
carvacrol, pinocembrin, chrysin, protocatechuic acid, 3. Romero-Calle D, Guimarães Benevides R, Góes-Neto A,
rutin, and salicylic acid. Billington C. Bacteriophages as alternatives to antibiotics in
clinical care. Antibiotics. 2019;8:138.
Acknowledgments doi: 10.3390/antibiotics8030138
The authors would like to acknowledge the Al-Qasemi 4. Harman RM, Yang S, He MK, Van de Walle GR.
Research Foundation and the Arab American University- Antimicrobial peptides secreted by equine mesenchymal
Palestine (AAUP) Research Foundation for the financial stromal cells inhibit the growth of bacteria commonly found
support provided. in skin wounds. Stem Cell Res Ther. 2017;8:157.

Volume 2 Issue 1 (2025) 86 doi: 10.36922/mi.4994