Page 95 - MI-2-1

Microbes & Immunity Hyphaene thebaica honey as a multitarget therapeutic product

doi: 10.1186/s13287-017-0610-6 Based Complement Altern Med. 2012;2012:940961.
5. Hobson C, Chan AN, Wright GD. The antibiotic resistome: doi: 10.1155/2012/940961
A guide for the discovery of natural products as antimicrobial
agents. Chem Rev. 2021;121(6):3464-3494. 17. Ben-Arye E, Massalha E, Bar-Sela G, et al. Stepping from
traditional to integrative medicine: Perspectives of Israeli-
doi: 10.1021/acs.chemrev.0c01214 Arab patients on complementary medicine’s role in cancer
care. Ann Oncol. 2014;2014:476-80.
6. Qanash H, Yahya R, Bakri MM, et al. Anticancer, antioxidant,
antiviral and antimicrobial activities of Kei Apple (Dovyalis doi: 10.1093/annonc/mdt554
caffra) fruit. Sci Rep. 2022;12:5914.
18. Ben-Arye E, Dagash J, Silbermann M, et al. Modelling
7. Abdelghany TM, Yahya R, Bakri MM, Ganash M, Amin BH, integrative oncology care program for Arab patients in
Qanash H. Effect of Thevetia peruviana seeds extract for North Israel: Towards quality of life improvement during
microbial pathogens and cancer control. Int J Pharmacol. chemotherapy. Harefuah. 2015;154:25-30.
2021;17:643-655.
19. Ben-Arye E, Schiff E, Mutafoglu K, et al. Integration of
doi: 10.3923/ijp.2021.643.655 complementary medicine in supportive cancer care: Survey
8. Maicelo-Quintana JL, Reyna-Gonzales K, Balcázar- of health care providers’ perspectives from 16 countries in
Zumaeta CR, Auquiñivin-Silva EA, Castro-Alayo EM, the Middle East. Support Care Cancer. 2015;23:2605-2612.
Medina-Mendoza M, et al. Potential application of bee doi: 10.1007/s00520-015-2619-7
products in food industry: An exploratory review. Heliyon.
2024;10:e24056 20. Candiracci M, Piatti E, Dominguez-Barragan M, et al.
Anti-inflammatory activity of a honey flavonoid extract on
doi: 10.1016/j.heliyon.2024.e24056 lipopolysaccharide-activated N13 microglial cells. J Agric
9. Saeed F, Afzaal M, Tufail T, Ahmad A. Use of natural Food Chem. 2012;60:12304-12311.
antimicrobial agents: A safe preservation approach. In: Active doi: 10.1021/jf302468h
Antimicrobial Food Packaging. London, UK: IntechOpen;
2019. 21. Xie F, Su M, Qiu W, et al. Kaempferol promotes apoptosis
in human bladder cancer cells by inducing the tumor
10. Ye G, Wu H, Huang J, et al. LAMP2: A major update of suppressor, PTEN. Int J Mol Sci. 2013;14:21215-21226.
the database linking antimicrobial peptides. Database.
2020;2020:baaa061. doi: 10.3390/ijms141121215
doi: 10.1093/database/baaa061 22. Furman D, Campisi J, Verdin E, et al. Chronic inflammation
in the etiology of disease across the life span. Nat Med.
11. Dixon B. Bacteria can’t resist honey. Lancet Infect Dis. 2019;25:1822-1832.
2003;3:116.
doi: 10.1038/s41591-019-0675-0
doi: 10.1016/s1473-3099(03)00524-3
23. Vonkeman HE, van de Laar MA. Nonsteroidal anti-
12. Snijders RA, Brom L, Theunissen M, van den Beuken-van inflammatory drugs: Adverse effects and their prevention.
Everdingen MH. Update on prevalence of pain in patients Semin Arthritis Rheum. 2010;39:294-312.
with cancer 2022: A systematic literature review and meta-
analysis. Cancers. 2023;15(3):591. doi: 10.1016/j.semarthrit.2008.08.001

doi: 10.3390/cancers15030591 24. Whitehouse MW. Anti-inflammatory glucocorticoid
drugs: Reflections after 60 years. Inflammopharmacology.
13. Chidambaram M, Manavalan R, Kathiresan K. 2010;19:1-19.
Nanotherapeutics to overcome conventional cancer
chemotherapy limitations. J Pharm Pharm Sci. 2011;14:67-77. doi: 10.1007/s10787-010-0056-2
doi: 10.18433/j30c7d 25. Saad B. Prevention and treatment of obesity-related
inflammatory diseases by edible and medicinal plants and
14. Mendel J. Evidenced based medicine. Benefits, limitations their active compounds. Immuno. 2022;2(4):609-629.
and issues for complementary and alternative medicine.
Aust J Holist Nurs. 2004;11:21-29. doi: 10.3390/immuno2040038
15. Waheed M, Hussain MB, Javed A, et al. Honey and cancer: 26. Alfadda AA, Sallam RM. Reactive oxygen species in health
A mechanistic review. Clini Nutr. 2019;38(6):2499-2503. and disease. J Biomed Biotechnol. 2012;2012:936486.
doi: 10.1016/j.clnu.2018.12.019 doi: 10.1155/2012/936486
16. Ben-Arye E, Cassileth B, Heusser P, Afifi F, Saad B, Senthamil 27. Shen N, Wang T, Gan Q, Liu S, Wang L, Jin B. Plant
RS. Complementary and integrative oncology in the cross- flavonoids: Classification, distribution, biosynthesis, and
cultural region of the Middle East and South Asia. Evid antioxidant activity. Food Chemistry. 2022;383:132531.

Volume 2 Issue 1 (2025) 87 doi: 10.36922/mi.4994