Page 59 - MI-2-2

Microbes & Immunity Role of SRCR proteins in inflammation

mucosal protection in vivo and a deletion variant is 19. Gao X, Yan X, Yin Y, et al. Therapeutic targeting of apoptosis
associated with Crohn’s disease. Gastroenterology. inhibitor of macrophage/CD5L in sepsis. Am J Respir Cell
2007;133(5):1499-1509. Mol Biol. 2019;60(3):323-334.
doi: 10.1053/j.gastro.2007.08.007 doi: 10.1165/rcmb.2018-0272OC
10. Rosenstiel P, Sina C, End C, et al. Regulation of DMBT1 20. Oliveira L, Silva MC, Gomes AP, et al. CD5L as a promising
via NOD2 and TLR4 in intestinal epithelial cells biological therapeutic for treating sepsis. Nat Commun.
modulates bacterial recognition and invasion. J Immunol. 2024;15(1):4119.
2007;178(12):8203-8211. doi: 10.1038/s41467-024-48360-8
doi: 10.4049/jimmunol.178.12.8203 21. Oliveira L, Carmo AM. Response: Commentary: The
11. Sanchez-Moral L, Rafols N, Martori C, Paul T, Tellez E, scavenger receptor SSc5d physically interacts with bacteria
Sarrias MR. Multifaceted roles of CD5L in infectious and through the SRCR-containing N-terminal domain. Front
sterile inflammation. Int J Mol Sci. 2021;22(8):4076. Immunol. 2017;8:1004.
doi: 10.3390/ijms22084076 doi: 10.3389/fimmu.2017.01004
12. Arai S, Miyazaki T. A scavenging system against internal 22. Tarakhovsky A, Kanner SB, Hombach J, et al. A role for
pathogens promoted by the circulating protein apoptosis CD5 in TCR-mediated signal transduction and thymocyte
inhibitor of macrophage (AIM). Semin Immunopathol. selection. Science. 1995;269(5223):535-537.
2018;40(6):567-575. doi: 10.1126/science.7542801
doi: 10.1007/s00281-018-0717-6 23. Vera J, Fenutría R, Cañadas O, et al. The CD5 ectodomain
13. Di Flora DC, Dionizio A, Pereira H, et al. Analysis of plasma interacts with conserved fungal cell wall components and
proteins involved in inflammation, immune response/ protects from zymosan-induced septic shock-like syndrome.
complement system, and blood coagulation upon admission Proc Natl Acad Sci U S A. 2009;106(5):1506-1511.
of COVID-19 Patients to hospital may help to predict the doi: 10.1073/pnas.0805846106
prognosis of the disease. Cells. 2023;12(12):1601.
24. Oliveira MI, Goncalves CM, Pinto M, et al. CD6 attenuates
doi: 10.3390/cells12121601 early and late signaling events, setting thresholds for T-cell
14. Yasuda K, Shimodan S, Maehara N, et al. AIM/CD5L activation. Eur J Immunol. 2012;42(1):195-205.
ameliorates autoimmune arthritis by promoting removal doi: 10.1002/eji.201040528
of inflammatory DAMPs at the lesions. J Autoimmun.
2024;142:103149. 25. Sarrias MR, Farnos M, Mota R, et al. CD6 binds to
pathogen-associated molecular patterns and protects
doi: 10.1016/j.jaut.2023.103149 from LPS-induced septic shock. Proc Natl Acad Sci U S A.
15. Fujii T, Yamawaki-Ogata A, Terazawa S, Narita Y, Mutsuga M. 2007;104(28):11724-11729.
Administration of an antibody against apoptosis inhibitor of doi: 10.1073/pnas.0702815104
macrophage prevents aortic aneurysm progression in mice.
Sci Rep. 2024;14(1):15878. 26. Carrasco E, Escoda-Ferran C, Climent N, et al. Human CD6
down-modulation following T-cell activation compromises
doi: 10.1038/s41598-024-66791-7 lymphocyte survival and proliferative responses. Front
16. Sanjurjo L, Amezaga N, Aran G, et al. The human CD5L/ Immunol. 2017;8:769.
AIM-CD36 axis: A novel autophagy inducer in macrophages doi: 10.3389/fimmu.2017.00769
that modulates inflammatory responses. Autophagy.
2015;11(3):487-502. 27. Ramos-Casals M, Font J, García-Carrasco M, et al. High
circulating levels of soluble scavenger receptors (sCD5
doi: 10.1080/15548627.2015.1017183 and sCD6) in patients with primary Sjögren’s syndrome.
17. Wang C, Yosef N, Gaublomme J, et al. CD5L/AIM regulates Rheumatology (Oxford). 2001;40(9):1056-1059.
lipid biosynthesis and restrains Th17 cell pathogenicity. Cell. doi: 10.1093/rheumatology/40.9.1056
2015;163(6):1413-1427.
28. Kragsnaes MS, Jensen JRB, Nilsson AC, et al. Dynamics
doi: 10.1016/j.cell.2015.10.068 of inflammation-associated plasma proteins following
faecal microbiota transplantation in patients with psoriatic
18. Weng D, Gao S, Shen H, et al. CD5L attenuates allergic
airway inflammation by expanding CD11c high alveolar arthritis and healthy controls: Exploratory findings from the
macrophages and inhibiting NLRP3 inflammasome FLORA trial. RMD Open. 2024;10(1):e003750.
activation via HDAC2. Immunology. 2022;167:384-397. doi: 10.1136/rmdopen-2023-003750
doi: 10.1111/imm.13543 29. Falcon Lincheta L, Saumell Napoles Y, Gray Lovio OR, et al.

Volume 2 Issue 2 (2025) 51 doi: 10.36922/mi.5741