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Microbes & Immunity Hyphae and healthspan

the magnitude of any such impact remains unknown. driven by epigenetic abnormalities. Diet and exercise —
182
However, as reducing dietary refined carbohydrates and their impact on the gut microbiome—are clearly
and alcohol intake is beneficial in numerous other ways, within our control.
the therapeutic approach appears straightforward.
Vitamin D3 and tryptophan both counteract the yeast- Acknowledgments
to-hyphae transition, whereas magnesium seems to None.
exhibit fungicidal properties. Although incorporating
141
sun exposure and supplemental vitamin D3 132,133 into Funding
one’s routine is unequivocally advantageous, consuming None.
tryptophan in amounts exceeding 4.5 g/day may be ill-
advised. Low-dose tryptophan can enhance mood and Conflict of interest
175
sleep. Most individuals following a Western diet have an
elevated body mass index and insulin resistance, which The author declares no conflict of interest.
is linked to CO. This condition can be mitigated by Author contributions
176
introducing a lactobacilli-rich probiotic, which not
172
only exhibits anticandidal properties but also helps This is a single-authored article.
177
modulate the immune response. Bifidobacteria and
178
lactobacilli may significantly contribute to enhancing Ethics approval and consent to participate
healthspan. The Western diet, typically high in calcium Not applicable.
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179
and low in magnesium, also upregulates zonulin, a
factor contributing to increased intestinal permeability. Consent for publication
Obesity is directly associated with ATM in both children Not applicable.
and adults 180,181 and is the leading factor potentially
explaining the otherwise inexplicable increase in early- Availability of data
onset cancers. Candida may ultimately be recognized as
a key facilitator, not only for other pathogens but also for Not applicable.
many autoantibodies – such as anti-gliadin antibodies, References
anti-Gq-coupled GPCR antibodies, anti-CCR antibodies,
ACPAs, and ANAs – that link cancer, dementia, ASCVD, 1. Li X, Li C, Zhang W, Wang Y, Qian P, Huang H. Inflammation
and systemic diseases. and aging: Signaling pathways and intervention therapies.
Signal Transduct Target Ther. 2023;8:239.
In summary, a healthy gut microbiome is increasingly
recognized as critical for healthspan and is characterized doi: 10.1038/s41392-023-01502-8
by the following: 2. Santos-Moreno P, Burgos-Angulo G, Martinez-
1) High biodiversity Ceballos MA, et al. Inflammaging as a link between
2) Microbiota rich in butyrogenic bacteria and their autoimmunity and cardiovascular disease: The case of
facilitators, such as lactobacilli and bifidobacteria 148,149 rheumatoid arthritis. RMD Open. 2021;7(1):e001470.
3) Optimal tryptophan metabolism, defined by a balance doi: 10.1136/rmdopen-2020-001470
between host IDO and fungal IDO 3. Mekli K, Lophatananon A, Maharani A, Nazroo JY,
CO opposes these conditions and promotes the Muir KR. Association between an inflammatory biomarker
following: score and future dementia diagnosis in the population-
1) Aberrant methylation, such as the 677T allele found in based UK Biobank cohort of 500,000 people. PLoS One.
136
most Americans (epigenetic) 2023;18(7):e0288045.
2) Insulin resistance, present in nearly half of the doi: 10.1371/journal.pone.0288045
population 4. Berben L, Floris G, Wildiers H, Hatse S. Cancer and aging:
3) DNA histone deacetylation (epigenetic), contributes Two tightly interconnected biological processes. Cancers
to pre-mature aging. 163 (Basel). 2021;13(6):1400.
Although these conclusions are conceptual and not doi: 10.3390/cancers13061400
empirically validated, they align with the 2,400-year-old 5. Zhu L, Tang Z, Hu R, Gu M, Yang, Y. Ageing and Inflammation
adage of Hippocrates. Although not all diseases originate in Periodontium. Encyclopedia; 2024. Available from:
in the gut, the gut microbiome appears to play a central https://encyclopedia.pub/entry/51981 [Last accessed on
role in initiating or potentiating most diseases, even those 2024 Dec 09].

Volume 2 Issue 3 (2025) 152 doi: 10.36922/mi.4736