Page 36 - MI-2-3
P. 36
Microbes & Immunity Correlation between VZV and cancer
58. Radhakrishnan V, Golla U, Kudva AK. Role of immune the innate immune response by varicella zoster virus. Front
cells and immunotherapy in multiple myeloma. Life (Basel). Immunol. 2020;11:1.
2024;14(4):461.
doi: 10.3389/fimmu.2020.00001
doi: 10.3390/life14040461
69. Jacobsen C, Pluckebaum N, Ssebyatika G, et al. Viral
59. Advani D, Kumar P. Uncovering cell cycle dysregulations and modulation of type II interferon increases T cell adhesion
associated mechanisms in cancer and neurodegenerative and virus spread. Nat Commun. 2024;15(1):5318.
disorders: A glimpse of hope for repurposed drugs. Mol doi: 10.1038/s41467-024-49657-4
Neurobiol. 2024;61(11):8600-8630.
70. Molinier-Frenkel V, Prevost-Blondel A, Castellano F. The
doi: 10.1007/s12035-024-04130-7 IL4I1 enzyme: A new player in the immunosuppressive
60. Zerboni L, Sung P, Lee G, Arvin A. Age-associated tumor microenvironment. Cells. 2019;8(7):757.
differences in infection of human skin in the SCID mouse doi: 10.3390/cells8070757
model of varicella-zoster virus pathogenesis. J Virol.
2018;92(11):e00002-18. 71. Cousin C, Aubatin A, Le Gouvello S, Apetoh L, Castellano F,
Molinier-Frenkel V. The immunosuppressive enzyme IL4I1
doi: 10.1128/JVI.00002-18 promotes FoxP3(+) regulatory T lymphocyte differentiation.
61. Oliver SL. The structures and functions of VZV Eur J Immunol. 2015;45(6):1772-1782.
glycoproteins. Curr Top Microbiol Immunol. 2023;438:25-58. doi: 10.1002/eji.201445000
doi: 10.1007/82_2021_243 72. Romagnani S. IL4I1: Key immunoregulator at a crossroads
62. Kaufer BB, Smejkal B, Osterrieder N. The varicella-zoster of divergent T-cell functions. Eur J Immunol. 2016;46(10):
virus ORFS/L (ORF0) gene is required for efficient viral 2302-2305.
replication and contains an element involved in DNA doi: 10.1002/eji.201646617
cleavage. J Virol. 2010;84(22):11661-11669.
73. Jiang J, Natarajan K, Margulies DH. MHC molecules,
doi: 10.1128/JVI.00878-10 T cell receptors, natural killer cell receptors, and viral
63. Rossi L, Tiecco G, Venturini M, Castelli F, Quiros-Roldan E. immunoevasins-key elements of adaptive and innate
Human orf with immune-mediated reactions: A systematic immunity. Adv Exp Med Biol. 2019;1172:21-62.
review. Microorganisms. 2023;11(5):1138. doi: 10.1007/978-981-13-9367-9_2
doi: 10.3390/microorganisms11051138 74. Wu Y, Zhang N, Hashimoto K, Xia C, Dijkstra JM. Structural
64. Ouwendijk WJD, Depledge DP, Rajbhandari L, et al. comparison between MHC classes I and II; in evolution, a
Varicella-zoster virus VLT-ORF63 fusion transcript induces class-II-like molecule probably came first. Front Immunol.
broad viral gene expression during reactivation from 2021;12:621153.
neuronal latency. Nat Commun. 2020;11(1):6324. doi: 10.3389/fimmu.2021.621153
doi: 10.1038/s41467-020-20031-4 75. Ye Y, Li S, Yan X, et al. VZV IE4 downregulates cellular
65. Eisfeld AJ, Turse SE, Jackson SA, Lerner EC, Kinchington PR. surface MHC-I via sequestering it to the Golgi complex. Cell
Phosphorylation of the varicella-zoster virus (VZV) Mol Life Sci. 2024;82(1):23.
major transcriptional regulatory protein IE62 by the VZV doi: 10.1007/s00018-024-05477-9
open reading frame 66 protein kinase. J Virol. 2006;80(4):
1710-1723. 76. Whitmer T, Malouli D, Uebelhoer LS, DeFilippis VR, Fruh K,
Verweij MC. The ORF61 protein encoded by simian
doi: 10.1128/JVI.80.4.1710-1723.2006 varicella virus and varicella-zoster virus inhibits NF-kappaB
66. Sen N, Sommer M, Che X, White K, Ruyechan WT, Arvin AM. signaling by interfering with Ikappabalpha degradation.
Varicella-zoster virus immediate-early protein 62 blocks J Virol. 2015;89(17):8687-8700.
interferon regulatory factor 3 (IRF3) phosphorylation at doi: 10.1128/JVI.01149-15
key serine residues: a novel mechanism of IRF3 inhibition
among herpesviruses. J Virol. 2010;84(18):9240-9253. 77. Abendroth A, Kinchington PR, Slobedman B. Varicella
zoster virus immune evasion strategies. Curr Top Microbiol
doi: 10.1128/JVI.01147-10 Immunol. 2010;342:155-171.
67. Borden EC. Interferons alpha and beta in cancer: doi: 10.1007/82_2010_41
Therapeutic opportunities from new insights. Nat Rev Drug 78. Abendroth A, Slobedman B. Modulation of MHC and
Discov. 2019;18(3):219-234.
MHC-like molecules by varicella zoster virus. Curr Top
doi: 10.1038/s41573-018-0011-2 Microbiol Immunol. 2023;438:85-102.
68. Gerada C, Campbell TM, Kennedy JJ, et al. Manipulation of doi: 10.1007/82_2022_254
Volume 2 Issue 3 (2025) 28 doi: 10.36922/mi.8320

