Page 7 - MSAM-2-2

Materials Science in

Additive Manufacturing

REVIEW ARTICLE
Advanced approaches with combination of 2D

nanomaterials and 3D printing for exquisite
neural tissue engineering

1†
1
1†
Hyo Jung Jo , Moon Sung Kang , Hee Jeong Jang ,
1,2
3
2
Iruthayapandi Selestin Raja , Dohyung Lim , Bongju Kim *, Dong-Wook Han *
4
1 Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 46241,
South Korea
2 BIO-IT Fusion Technology Research Institute, Pusan National University, Busan 46241, South Korea
3 Department of Mechanical Engineering, Sejong University, Seoul 05006, South Korea
4 Dental Life Science Research Institute/Innovation Research and Support Center for Dental Science,
Seoul National University Dental Hospital, Seoul 03080, South Korea

Abstract

The regeneration of neural tissue presents significant challenges due to the complexity
of the nervous system, which can be damaged by traumatic and non-traumatic
injuries. Traditional approaches to repairing nerve damage, such as transplantation of
† These authors contributed equally auto-, allo-, or xeno-grafts, have limitations. Recently, researchers have been studying
to this work. the use of two-dimensional (2D) nanomaterials as novel therapeutic approaches
*Corresponding authors: for treating neurological disorders. This review first presents the classification of
Bongju Kim 2D nanoparticles for neural regeneration and their biocompatibility. Thereafter, we
(bjkim016@gmail.com)
Dong-Wook Han discuss the recent approaches combining 2D nanomaterials and three-dimensional
(nanohan@pusan.ac.kr) (3D) printing to produce hydrogel-based scaffolds for exquisite neural tissue
engineering. Furthermore, recent highlighted studies focusing on the combination
Citation: Jo HJ, Kang MS,
Jang HJ, et al., 2023, Advanced of 2D nanomaterials and 3D bioprinting for neural tissue engineering are specially
approaches with combination of 2D introduced. Through this review, we aim to contribute to crafting a range of strategies
nanomaterials and 3D printing for for the biomedical applications of 3D printing with diverse nanomaterials and hope
exquisite neural tissue engineering.
Mater Sci Add Manuf, 2(2): 0620. to encourage further research on understanding the mechanisms of toxicity as well
https://doi.org/10.36922/msam.0620 as the synergistic effects of 2D nanomaterials and hydrogel scaffolds for neural tissue
Received: April 19, 2023 engineering and regeneration.
Accepted: May 23, 2023
Keywords: 3D Printing; 2D Nanomaterials; Hydrogel; Neural tissue engineering;
Published Online: June 7, 2023
Biocompatibility
Copyright: © 2023 Author(s).
This is an Open Access article
distributed under the terms of the
Creative Commons Attribution
License, permitting distribution, 1. Introduction
and reproduction in any medium,
provided the original work is The nervous system can be categorized into two primary divisions: the central nervous
properly cited. system (CNS) and the peripheral nervous system (PNS). The CNS is composed of
Publisher’s Note: AccScience the brain and spinal cord, whereas the PNS consists of motor and sensory neurons
Publishing remains neutral with responsible for transmitting signals from the CNS to the other parts of the body. Due to
regard to jurisdictional claims in
published maps and institutional the anatomical and physiological complexity of the nervous system, the regeneration of
[1]
affiliations. neural tissue presents significant challenges . CNS damage can result from traumatic

Volume 2 Issue 2 (2023) 1 https://doi.org/10.36922/msam.0620