Page 7 - MSAM-4-2

Materials Science in

Additive Manufacturing

REVIEW ARTICLE
Hydrogel-based materials for mandibular

reconstruction

7
Yiwen Zhang 1,2,3,4,5,6† , Yilan Sun 1,2,3,4,5,6† , Jiacheng Luo , Zilin Wang ,
2
Zimo Pang , Yujie Chen , and Jiannan Liu 1,2,3,4,5,6 *
8
8
1 Department of Oral and Maxillofacial Head and Neck Oncology, Shanghai Ninth People’s Hospital,
Shanghai Jiao Tong University School of Medicine, Shanghai, China
2 College of Stomatology, Shanghai Jiao Tong University, Shanghai, China
3 National Center for Stomatology, Shanghai, China
4 National Clinical Research Center for Oral Diseases, Shanghai, China
5 Shanghai Key Laboratory of Stomatology, Shanghai, China
6 Shanghai Research Institute of Stomatology, Shanghai, China
7 Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Jilin University,
Changchun, Jilin, China
8 School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, China

Abstract
† These authors contributed equally
to this work Mandibular reconstruction remains a significant clinical challenge due to irregular
defect geometries, high functional restoration requirements, and complex oral
*Corresponding author: environments. Traditional vascularized bone grafts, while effective, are limited by
Jiannan Liu
(liujiannan@sh9hospital.org.cn) donor site complications and poor osseointegration. Hydrogel-based materials have
emerged as promising alternatives due to their biocompatibility, tunable mechanical
Citation: Zhang Y, Sun Y, Luo J,
et al. Hydrogel-based materials properties, and capacity to mimic the extracellular matrix for osteogenesis and
for mandibular reconstruction. angiogenesis. This review highlights recent advances in hydrogel design strategies
Mater Sci Add Manuf. tailored for mandibular regeneration. Key considerations include mechanical
2025;4(2):025070006.
doi: 10.36922/MSAM025070006 reinforcement through nanocomposites and dual-network architectures, which
enhance compressive strength and toughness to withstand masticatory loads.
Received: February 2, 2025 Injectable hydrogels demonstrate minimally invasive delivery and shape adaptability
Revised: March 20, 2025 for irregular defects, while biomimetic wet adhesives achieve robust tissue integration
Accepted: April 4, 2025 through covalent and coordination bonding mechanisms. Functionalization with
bioactive factors and stem cells promotes spatiotemporal regulation of osteogenesis
Published online: April 29, 2025 and angiogenesis, as evidenced by successful mandibular regeneration in preclinical
Copyright: © 2025 Author(s). models. Antibacterial strategies integrating metal ions, antibacterial agents, or
This is an Open-Access article peptides can contribute to addressing oral microbial challenges. This review
distributed under the terms of the
Creative Commons Attribution underscores the potential of multifunctional hydrogels to bridge structural and
License, permitting distribution, functional regeneration in craniofacial reconstruction while identifying critical
and reproduction in any medium, research gaps for future innovation.
provided the original work is
properly cited.
Publisher’s Note: AccScience Keywords: Polymer materials; Hydrogel biomaterials; Mandibular reconstruction;
Publishing remains neutral with Nanocomposite reinforcement; Injectable hydrogel systems; Bioinspired wet-adhesive
regard to jurisdictional claims in
published maps and institutional interfaces; Oral antibacterial strategies; 3D Printing
affiliations.

Volume 4 Issue 2 (2025) 1 doi: 10.36922/MSAM025070006