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6. Limitations Conflict of interest
Although bibliometrics is a widely used method for The authors declare that there are no conflicts of interest
assessing the impact of articles, our present study has several regarding the publication of this paper.
limitations. First, the data on bone/cartilage organoids were
primarily sourced from the WOS database, which may Author contributions
have resulted in the omission of relevant publications from Conceptualization: Aikang Li, Rongji Liang, Fuyang Cao
other databases. Second, our study focused exclusively on Data curation: Aikang Li, Rongji Liang, Weibei Sheng
English-language articles, potentially excluding significant Formal analysis: Weibei Sheng, Peng Liu
research published in other languages. Finally, while older Funding acquisition: Jianjing Lin
research typically accumulates higher citation counts, such Methodology: Jianjing Lin, Liang Gao
articles may no longer reflect present trends or emerging Project administration: Yanbin Peng
hot topics in the field. Furthermore, high-quality papers Supervision: Jianjing Lin, Xiaohao Wu
may not receive adequate attention due to lower citation Visualization: Aikang Li, Rongji Liang
counts, creating a gap between bibliometric analysis and
real-world impact. Writing - original draft: Aikang Li, Rongji Liang, Weibei
Sheng, Weijin Guo, Peng Liu
7. Conclusion Writing - review & editing: Hui Zeng, Yanbin Peng, Jianjing Lin

Our bibliometric study of bone and cartilage organoids Ethics approval and consent to participate
reveals a growing interest in this field. The USA emerged
as the most influential country in terms of research output Not applicable.
and publication quality. A comprehensive analysis of Consent for publication
publications and citations identified Bioactive Materials
as the most influential journal. Jiacan Su from China and Not applicable.
Hans Clevers from the Netherlands were the most prolific
and impactful authors, respectively. Annual publication Availability of data
data indicate a steady increase in publications since 2010, The data and materials used in this study are available from
peaking in 2023, suggesting that research in this area the corresponding author upon reasonable request.
will continue to expand. Across the analysis of journals
and keywords, we identified four primary research References
directions and the trends they represent. Present research 1. Zhang H, Wu S, Chen W, Hu Y, Geng Z, Su J. Bone/cartilage
in bone/cartilage organoids is advancing in several key targeted hydrogel: Strategies and applications. Bioact Mater.
areas: stem cells and the microenvironment play a critical 2022;23:156-169.
role in developing accurate tissue regeneration models;
innovations in biomaterials are enhancing organoid growth doi: 10.1016/j.bioactmat.2022.10.028
and functionality; organoids are enabling personalized 2. Pigeolet M, Jayaram A, Park KB, Meara JG. Osteoarthritis in
treatments for diseases, such as osteoarthritis in regenerative 2020 and beyond. Lancet. 2021;397(10279):1059-1060.
medicine; and their application in disease modeling doi: 10.1016/S0140-6736(21)00208-7
and drug screening offers valuable platforms for testing
therapies. Future research will likely focus on refining these 3. Compston JE, McClung MR, Leslie WD. Osteoporosis.
models for clinical and pharmaceutical applications. Lancet. 2019;393(10169):364-376.
doi: 10.1016/S0140-6736(18)32112-3
Acknowledgments
4. Armiento AR, Alini M, Stoddart MJ. Articular
None. fibrocartilage - Why does hyaline cartilage fail to repair? Adv
Drug Deliv Rev. 2019;146:289-305.
Funding
doi: 10.1016/j.addr.2018.12.015
This study was supported by the Guangdong Basic and 5. Johnstone B, Alini M, Cucchiarini M, et al. Tissue engineering
Applied Basic Research Foundation (project numbers: for articular cartilage repair--the state of the art. Eur Cell
2023A1515220019, 2022A1515220056), the Sanming Project Mater. 2013;25:248-267.
of Medicine in Shenzhen (project number: SZSM202211019),
the “Merro” Young Physician Innovation and Development doi: 10.22203/ecm.v025a18
Project (project number: GSKQNJJ-2023-004), and the 6. Xue N, Ding X, Huang R, et al. Bone tissue engineering
Shenzhen Science and Technology Program (project in the treatment of bone defects. Pharmaceuticals (Basel).
number: JCYJ20240813115833044). 2022;15(7):879.

Volume 1 Issue 3 (2025) 13 doi: 10.36922/or.8295