Page 93 - OR-1-3
P. 93
phenotype in a cartilage-on-a-chip model. Nat Biomed Eng. 209. Marcacci M, Kon E, Zaffagnini S, et al. Reconstruction
2019;3:545-557. of extensive long-bone defects in sheep using porous
hydroxyapatite sponges. Calcif Tissue Int. 1998;64:83-90.
doi: 10.1038/s41551-019-0406-3
doi: 10.1007/s002239900583
198. Lin X, Lin T, Wang X, et al. Sesamol serves as a p53
stabilizer to relieve rheumatoid arthritis progression and 210. Mikael PE, Golebiowska AA, Kumbar SG, Nukavarapu SP.
inhibits the growth of synovial organoids. Phytomedicine. Evaluation of autologously derived biomaterials and
2023;121:155109. stem cells for bone tissue engineering. Tissue Eng Part A.
2020;19:1052-1063.
doi: 10.1016/j.phymed.2023.155109
doi: 10.1089/ten.TEA.2020.0011
199. Wang X, He J, Zhang Q, He J, Wang Q. Constructing a 3D
co-culture in vitro synovial tissue model for rheumatoid 211. Vainieri ML, Wahl D, Alini M, van Osch GJVM, Grad S.
arthritis research. Mater Today Bio. 2025;31:101492. Mechanically stimulated osteochondral organ culture for
evaluation of biomaterials in cartilage repair studies. Acta
doi: 10.1016/j.mtbio.2025.101492
Biomater. 2018;81:256-266.
200. Nie JH, Yang T, Li H, et al. Frequently expressed glypican‐3
as a promising novel therapeutic target for osteosarcomas. doi: 10.1016/j.actbio.2018.09.058
Cancer Sci. 2022;113:3618-3632. 212. Chen W, Liu D, Lu K, et al. Organoids of musculoskeletal
system for disease modeling, drug screening, and
doi: 10.1111/cas.15521
regeneration. Adv Healthc Mater. 2025;14:e2402444.
201. Suzuki R, Wakamatsu T, Yoshida K, et al. Genetic
characterization of a novel organoid from human malignant doi: 10.1002/adhm.202402444
giant-cell tumor. J Bone Oncol. 2023;41:100486. 213. Rossi G, Manfrin A, Lutolf MP. Progress and potential in
organoid research. Nat Rev Genet. 2018;19:671-687.
doi: 10.1016/j.jbo.2023.100486
doi: 10.1038/s41576-018-0051-9
202. Forsythe SD, Sivakumar H, Erali RA, et al. Patient-specific
sarcoma organoids for personalized translational research: 214. Hu Y, Zhang H, Wang S, et al. Bone/cartilage organoid
Unification of the operating room with rare cancer research on-chip: Construction strategy and application. Bioact
and clinical implications. Ann Surg Oncol. 2022;29:7354-7367. Mater. 2023;25:29-41.
doi: 10.1245/s10434-022-12086-y doi: 10.1016/j.bioactmat.2023.01.016
203. Parvatam S, Pistollato F, Marshall LJ, et al. Human-based 215. Editorial. An update on organoid research. Nat Cell Biol.
complex in vitro models: Their promise and potential for rare 2018;20:633.
disease therapeutics. Front Cell Dev Biol. 2025;13:1526306.
doi: 10.1038/s41556-018-0119-y
doi: 10.3389/fcell.2025.1526306
216. Wan A. Recapitulating cell-cell interactions for organoid
204. Sun D, Gao W, Hu H, Zhou S. Why 90% of clinical drug construction - are biomaterials dispensable? Trends
development fails and how to improve it? Acta Pharm Sin B. Biotechnol. 2016;34:711-721.
2022;12:3049-3062.
doi: 10.1016/j.tibtech.2016.02.015
doi: 10.1016/j.apsb.2022.02.002
217. Holloway EM, Capeling MM, Spence JR. Biologically
205. Orloff J, Douglas F, Pinheiro J, et al. The future of drug inspired approaches to enhance human organoid complexity.
development: Advancing clinical trial design. Nat Rev Drug Development. 2019;146:dev166173.
Discov. 2009;8:949-957.
doi: 10.1242/dev.166173
doi: 10.1038/nrd3025
218. Gao Q, Wang J, Zhang H, Wang J, Jing Y, Su J. Organoid
206. Sedgwick P. What are the four phases of clinical research vascularization: Strategies and applications. Adv Healthc
trials? BMJ. 2014;348:3727. Mater. 2025;14:e2500301.
doi: 10.1136/bmj.g3727 doi: 10.1002/adhm.202500301
207. Chen S, Liu D, Guo Q, et al. Facile construction of 219. Shin Y, Safina D, Zheng Y, Levenberg S. Microvascularization
mechanically robust and highly osteogenic materials for in 3D human engineered tissue and organoids. Annu Rev
bone regeneration. Mater Today Bio. 2025;32:101809. Biomed Eng. 2025;27:473-498.
doi: 10.1016/j.mtbio.2025.101809 doi: 10.1146/annurev-bioeng-103023-115236
208. Sharma B, Fermanian S, Gibson M, et al. Human cartilage 220. Zurlo F, Larson K, Bogardus C, Ravussin E. Skeletal muscle
repair with a photoreactive adhesive-hydrogel composite. Sci metabolism is a major determinant of resting energy
Transl Med. 2013;5:167ra166. expenditure. J Clin Invest. 1990;86:1423-1427.
doi: 10.1126/scitranslmed.3004838 doi: 10.1172/jci114857
Volume 1 Issue 3 (2025) 35 doi: 10.36922/OR025280024

