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Tumor Discovery

REVIEW ARTICLE
Receptors of advanced glycation end products

in oral squamous cell carcinoma: A systematic
review

Sinduja Palati*, Pratibha Ramani, and Saravanan Sekaran

Department of Oral and Maxillofacial pathology, Saveetha Dental College and Hospitals, Saveetha
Institute for Medical and Technical Sciences, Chennai, Tamil Nadu, India

Abstract

Oxidative stress markers have been shown to be elevated in oral squamous cell
carcinomas; plays a crucial role in the build-up of advanced glycation end-receptors
of advanced glycation end (AGE-RAGE) products; and has been shown to exacerbate
cellular dysfunction, vascular change, apoptosis, and activate inflammatory
pathways. The purpose of this study is to assess comprehensively the involvement
of RAGE in oral squamous cell malignancies. The findings imply that these receptors
and their associated ligands play a significant role in the growth and spread of the
tumor, hence impacting the prognosis and life expectancy of the affected individual.
This comprehensive review uncovers promising evidence for the clinical use of these
molecules, such as RAGEs, in prognostic considerations or as molecular targets for
therapy. The available literature shows a role for RAGE in invasion, migration, and
angiogenesis in oral cancers. These preliminary findings are encouraging for the
therapeutic use of these molecules for prognostic considerations or molecularly
targeted therapy.
*Corresponding author:
Sinduja Palati
(sindujap.sdc@saveetha.com) Keywords: Receptors of advanced glycation end products; Advanced glycation end
Citation: Palati S, Ramani P, products; Oral squamous cell carcinoma; Oral cancers
Sekaran S, 2023, Receptors of
advanced glycation end products
in oral squamous cell carcinoma:
A systematic review. Tumor Discov,
2(1): 244. 1. Introduction
https://doi.org/10.36922/td.244
Oral squamous cell carcinoma (OSCC) is the sixth most common type of cancer in the
Received: November 2, 2022
Accepted: January 27, 2023 world. OSCC accounts for at least 40% of all cancers; it is especially prevalent in India and
Published Online: February 10, 2023 Sri Lanka. OSCC is a complex cancer in which genetic mutations, environmental factors,
[1]
Copyright: © 2023 Author(s). and other risks contribute considerably to its malignancy . Local growth and lymph
This is an Open Access article node metastasis are intrinsically linked to the malignant potential of OSCC . It has been
[2]
distributed under the terms of the established that oxidative stress is enhanced in oral cancers and plays a significant role in
Creative Commons Attribution
License, permitting distribution, the build-up of several toxic substances. Oxidative stress is characterized by an imbalance
and reproduction in any medium, between the production of free radicals and antioxidants. In addition, it is illustrated by
provided the original work is
properly cited. a phenomenon implicated in the pathophysiology of numerous inflammatory disorders
and cancers.
Publisher’s Note: AccScience
Publishing remains neutral with Glycation is a non-enzymatic, spontaneous interaction between free reducing sugars
regard to jurisdictional claims in
published maps and institutional and free amino groups of proteins, DNA, and lipids that result in the creation of Amadori
affiliations. products. Multiple irreversible dehydration and rearrangement result in the formation

Volume 2 Issue 1 (2023) 1 https://doi.org/10.36922/td.244