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Tumor Discovery RAGEs in oral squamous cell carcinoma

Limitations Not mentioned Tumor thickness cannot be determined on biopsy derived material No correlations between RAGE and histological differentiation

Inference RAGE-H suggests low disease-free survival rate. The RAGE expression decreases in OSCC as they become less differentiated RAGE plays a function in the expression of VEGF in tumors, which is linked to tumor angiogenesis

P-value P < 0.00001 P < 0.05 P = 0.0123 and 0.0344, respectively

Observation The disease-free survival rate of RAGE-H patients was considerably lower than that of individuals with a low grade. 10 of 10 (100%) well- differentiated OSCCs were RAGE-positive, while 0 of 8 (0%) were poorly differentiated. Reduced band intensity at the molecular weight 55 kDa, seen more in OSCC than normal control. HSC-3 and HSC-4 cells treated with RAGE antisense S-ODN secreted considerably l

Method IHC IHC Western Blot Elisa RAGE: Receptors of advanced glycation end products, VEGF: Vascular endothelial growth factor, AGE: Advanced glycation end products, IHC: Immunohistochemistry, PCR: Polymerase chain

Marker RAGE RAGE RAGE VEGF

Control _ 14 20

Case 74 38 20

Cell line _ _

Table 1. (Continued) Number Study of samples 74 Sasahira et al. [16] 50 Landesberg et al. [22] 40 Sasahira et al. [23] reaction

Volume 2 Issue 1 (2023) 4 https://doi.org/10.36922/td.244