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Tumor Discovery Mechanism of Buddleja officinalis against ESCC

Table 1. Main active ingredients in BO
No. ID Ingredient Molecular Oral bioavailability (%) Drug likeness Chemical structure
weight
1 MOL001689 Acacetin 284.26 34.97 0.24

2 MOL001790 Linarin 592.5 39.84 0.71

3 MOL000006 Luteolin 286.24 36.16 0.25

4 MOL006673 Butyrospermyl 468.84 46.04 0.83
acetate

5 MOL000004 Procyanidin B1 578.5 67.87 0.66

6 MOL005789 Neobyakangelicol 316.33 36.18 0.31

Abbreviation: BO: Buddleja officinalis.

luteolin, butyrospermyl acetate, and neobyakangelicol maps of the binding of the above six components to
increased sequentially, with linarin expressing a strong AKT1.
affinity with AKT1 and engaging in the most stable
binding with AKT1. It is speculated that linarin may be 4. Discussion
the most suitable natural component of AKT1 in BO. The mechanism of TCM treatment is complex, involving
Figure 7 shows three-dimensional and two-dimensional many components and targets. It is a challenge in

Volume 3 Issue 1 (2024) 5 https://doi.org/10.36922/td.2312